{"id":"W3107982397","doi":"10.3390/ijms21228877","title":"The Impact of Radiation-Induced DNA Damage on cGAS-STING-Mediated Immune Responses to Cancer","year":2020,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":218,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; University of Alberta; Government of Alberta","keywords":"Immune system; Stimulator of interferon genes; Cancer research; DNA damage; Sting; Radiation therapy; Innate immune system; Immunogenic cell death; Context (archaeology); Cancer; Signal transduction; Immunotherapy; Immunology; Biology; Medicine; Cell biology; DNA; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002258419,0.0003096909,0.0002213811,0.000296815,0.0001418474,0.0003296319,0.0001584137,0.0002918969,0.001417846],"category_scores_gemma":[0.0001668674,0.00008182072,0.0003115706,0.0001368983,0.0001853077,0.0003063421,0.0002348155,0.0005709983,0.0003032809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768576,"about_ca_system_score_gemma":0.0003318239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001737879,"about_ca_topic_score_gemma":0.0003685534,"domain_scores_codex":[0.9998747,0.00003331166,0.00001094338,0.00001437012,0.00003667467,0.00002988279],"domain_scores_gemma":[0.9999176,0.00002139915,0.00002448247,0.00000484799,0.00001692534,0.00001480662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004121412,0.0001190817,0.001827112,0.001789937,0.00006348958,0.0003247201,0.0001311798,0.0007970934,0.8851993,0.002112797,0.001060753,0.1061623],"study_design_scores_gemma":[0.00003642377,0.0036386,0.02495799,0.0003651241,0.0002095096,0.001999403,0.0002076973,0.001577365,0.8668258,0.001927693,0.09822132,0.00003307944],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5259503,0.438029,0.01308357,0.001943303,0.0006362539,0.0002091653,0.0005666931,0.0003135131,0.01926822],"genre_scores_gemma":[0.8350008,0.1515746,0.005024113,0.0008125674,0.0003078904,0.0001037642,0.0005463801,0.000030835,0.006599102],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001417846,"threshold_uncertainty_score":0.004743159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0403741128775902,"score_gpt":0.390435130168848,"score_spread":0.3500610172912578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}