{"id":"W3108001297","doi":"10.1002/art.41600","title":"RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of <i>IL11</i> and <i>CHADL</i> as Attractive Treatment Targets","year":2020,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Seventh Framework Programme; ZonMw; Medical Delta; Universiteit Leiden; Leids Universitair Medisch Centrum; European Commission; Arthritis Society; Dutch Arthritis Society","keywords":"Cartilage; Osteoarthritis; Gene; Subchondral bone; Articular cartilage; Medicine; Biology; Bioinformatics; Computational biology; Genetics; Pathology; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001574685,0.0002003666,0.0002486193,0.0003053186,0.0001641205,0.000267569,0.0001116515,0.0001905443,0.001063022],"category_scores_gemma":[0.0002859762,0.0001108775,0.000256847,0.0002170886,0.0001773559,0.00008095289,0.0001477146,0.0001968914,0.0002670634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001753041,"about_ca_system_score_gemma":0.0002012778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005987213,"about_ca_topic_score_gemma":0.001351851,"domain_scores_codex":[0.9998301,0.00002210139,0.00001147143,0.00005554669,0.00004298448,0.00003768296],"domain_scores_gemma":[0.9997862,0.00005560642,0.00008740346,0.00001222764,0.00003063057,0.00002795503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003458494,0.00001735801,0.01717255,0.00007365683,0.00002756129,0.00008106874,0.00003829482,0.0001307953,0.977749,0.00004839492,0.00007438895,0.00424104],"study_design_scores_gemma":[0.00008169933,0.000863674,0.6530135,0.00004437013,0.0002427101,0.001185158,0.0004236481,0.003487048,0.3372148,0.000218161,0.003204779,0.00002036242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943444,0.001109369,0.002861048,0.00007652017,0.0000105285,0.00002694388,0.0009519671,0.00002766653,0.0005915901],"genre_scores_gemma":[0.993449,0.0003975618,0.003405411,0.0001404184,0.00001657657,0.00005735615,0.001709806,0.00001722955,0.0008067532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001063022,"threshold_uncertainty_score":0.003556132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631128333823578,"score_gpt":0.2647354840085362,"score_spread":0.2484242006703005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}