{"id":"W3108001297","doi":"10.1002/art.41600","title":"RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of <i>IL11</i> and <i>CHADL</i> as Attractive Treatment Targets","year":2020,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Seventh Framework Programme; ZonMw; Medical Delta; Universiteit Leiden; Leids Universitair Medisch Centrum; European Commission; Arthritis Society; Dutch Arthritis Society","keywords":"Cartilage; Osteoarthritis; Gene; Subchondral bone; Articular cartilage; Medicine; Biology; Bioinformatics; Computational biology; Genetics; Pathology; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002385794,0.0002889035,0.00115872,0.0001704335,0.00009940193,0.00002197127,0.00004697694,0.0001661014,0.00002112406],"category_scores_gemma":[0.0005023999,0.0003025755,0.0001058792,0.0001972275,0.0001936012,0.0003653807,0.00007180239,0.0001830848,0.000007923793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007616355,"about_ca_system_score_gemma":0.0001004204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002655213,"about_ca_topic_score_gemma":0.0005845448,"domain_scores_codex":[0.9975454,0.0001598951,0.00115363,0.0005415605,0.0001963676,0.000403151],"domain_scores_gemma":[0.9985595,0.0002733599,0.0006106565,0.0002185338,0.0001221034,0.0002158992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004680495,0.0001223994,0.09824517,0.0002319074,0.00002742866,0.0008224666,0.009612173,0.000001737871,0.8027481,0.0001921596,0.000005987264,0.08752241],"study_design_scores_gemma":[0.008931243,0.004195223,0.002249238,0.001816142,0.0001113534,0.003069536,0.005048978,0.0001058604,0.9739105,0.00022493,0.00006689695,0.0002700619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904072,0.008055641,0.00002434724,0.0004010256,0.0001482963,0.0007501434,0.000031915,0.00003680314,0.0001446099],"genre_scores_gemma":[0.9963959,0.002711033,0.0006316153,0.00009775574,0.00001696354,0.00006597297,0.00002670154,0.00003641332,0.00001768572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1711624,"threshold_uncertainty_score":0.9999427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631128333823578,"score_gpt":0.2647354840085362,"score_spread":0.2484242006703005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}