{"id":"W3108065468","doi":"10.18433/jpps30927","title":"Population pharmacokinetic models of first choice beta-lactam antibiotics for severe infections treatment: What antibiotic regimen to prescribe in children?","year":2020,"lang":"en","type":"review","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé","keywords":"Antibiotics; Regimen; Medicine; Beta-lactam; Pharmacokinetics; Intensive care medicine; Population; Pharmacology; Internal medicine; Microbiology; Biology; Environmental health","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006727347,0.001257347,0.003992705,0.002189898,0.0001557106,0.002208379,0.001539485,0.001440207,0.002668798],"category_scores_gemma":[0.02267288,0.000574339,0.006476044,0.002758235,0.0002835726,0.001808261,0.0005323866,0.001365252,0.000516244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001711163,"about_ca_system_score_gemma":0.003424674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003926453,"about_ca_topic_score_gemma":0.00311481,"domain_scores_codex":[0.9954517,0.002757665,0.0007508229,0.0003521174,0.0006110623,0.0000766828],"domain_scores_gemma":[0.9788119,0.01712071,0.002992743,0.0002071714,0.0007810785,0.00008637283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002362539,0.0002750938,0.02651727,0.4438104,0.04714573,0.001072942,0.0004676117,0.08335596,0.001399935,0.0108851,0.01555866,0.3671488],"study_design_scores_gemma":[0.002851563,0.004385633,0.05446047,0.3064305,0.1626125,0.0068852,0.0009980155,0.1281721,0.002955566,0.06511758,0.2644633,0.0006677404],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005425505,0.9782838,0.01052596,0.002241775,0.0001573113,0.0002575817,0.001880149,0.00005725061,0.001170644],"genre_scores_gemma":[0.1209989,0.8580924,0.01552502,0.001488423,0.0003897437,0.0009892752,0.001984875,0.00003386999,0.0004975859],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006727347,"threshold_uncertainty_score":0.03557807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1331691195084332,"score_gpt":0.4439452090278845,"score_spread":0.3107760895194512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}