{"id":"W3108070988","doi":"10.1016/j.euros.2020.11.005","title":"High Serine-arginine Protein Kinase 1 Expression with PTEN Loss Defines Aggressive Phenotype of Prostate Cancer Associated with Lethal Outcome and Decreased Overall Survival","year":2020,"lang":"en","type":"article","venue":"European Urology Open Science","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; University of Alberta; University of Calgary","funders":"Prostate Cancer Canada; Prostate Cancer Foundation","keywords":"PTEN; Prostate cancer; Hazard ratio; Medicine; Androgen deprivation therapy; Cohort; Prostate; Proportional hazards model; Biochemical recurrence; Oncology; Internal medicine; Cancer research; Cancer; Erg; Confidence interval; Biology; Prostatectomy; Apoptosis; PI3K/AKT/mTOR pathway; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006834097,0.0002254902,0.0004611112,0.00008274397,0.0001924898,0.00006719705,0.0005313545,0.00003196505,0.00008559893],"category_scores_gemma":[0.0004859469,0.0001313024,0.00002005453,0.0005524171,0.001366831,0.0002963288,0.0005903854,0.0002509098,0.000007469721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000461919,"about_ca_system_score_gemma":0.0005000054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002673887,"about_ca_topic_score_gemma":0.00004767596,"domain_scores_codex":[0.9978153,0.000264407,0.0002682593,0.000669394,0.0005339299,0.0004487068],"domain_scores_gemma":[0.9985614,0.00006808045,0.0003377087,0.000280108,0.0003745486,0.0003781828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01337183,0.0002615307,0.875691,0.0001080893,0.0001221168,0.002650368,0.00109081,0.0001376202,0.1053206,0.0001072032,0.00009058381,0.001048235],"study_design_scores_gemma":[0.01590219,0.005749944,0.9476609,0.0004700555,0.0001334319,0.00004835839,0.0001445121,0.0002295772,0.02899953,0.00001723742,0.000282671,0.000361663],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991146,0.000247362,0.0000175631,0.00596771,0.00003338849,0.001273604,0.00005624392,0.00003686185,0.001221225],"genre_scores_gemma":[0.9979602,0.00004071742,0.0006472035,0.0006268217,0.0000381862,0.0000509641,0.00003289603,0.0000355191,0.0005674828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0763211,"threshold_uncertainty_score":0.5354356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03888586670922312,"score_gpt":0.3135505300692982,"score_spread":0.2746646633600751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}