{"id":"W3108089428","doi":"10.1101/2020.11.25.398586","title":"Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Genomics; National Institutes of Health; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; Pfizer","keywords":"Small molecule; Bromodomain; Antagonist; Histone; Chemistry; Computational biology; Genetics; Cell biology; Biology; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002176087,0.0004336048,0.0004379211,0.0002559832,0.0001685754,0.0003303199,0.0003866077,0.0003280334,0.001369698],"category_scores_gemma":[0.0001437049,0.0001844179,0.0002672852,0.00013217,0.0002190518,0.0001168868,0.0002327498,0.0006427403,0.0003968624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004512943,"about_ca_system_score_gemma":0.0002490228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006635591,"about_ca_topic_score_gemma":0.00170837,"domain_scores_codex":[0.9998999,0.00001792797,0.000005426619,0.00001577792,0.00003628584,0.00002475508],"domain_scores_gemma":[0.9999404,0.00001326676,0.00001290372,0.000004815953,0.000009297948,0.00001932827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001835954,0.00008099213,0.0001947456,0.00004783396,0.00002735669,0.00006556116,0.00001366351,0.0004975062,0.9947186,0.000304317,0.0002380943,0.003627846],"study_design_scores_gemma":[0.0001933251,0.001199939,0.001141609,0.000007391308,0.00004263468,0.0002669884,0.000017331,0.00266199,0.9856753,0.00008116096,0.008700088,0.00001235073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777662,0.00347175,0.0120015,0.0003747472,0.0000825415,0.0003151512,0.001061315,0.0002322758,0.004694479],"genre_scores_gemma":[0.9836822,0.002011078,0.00759932,0.000201381,0.00002037963,0.0001982211,0.001243817,0.00003449823,0.005009019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369698,"threshold_uncertainty_score":0.004582047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227165887573835,"score_gpt":0.2203578524743226,"score_spread":0.2080861935985842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}