{"id":"W3108095856","doi":"10.17504/protocols.io.x34fqqw","title":"Transfection of constructs in diplonemids to enhance the HR pathway, using RS-1 (3-(benzylamino) sulfonyl)-4-bromo-N-(4-bromophenyl) benzamide). v2","year":2019,"lang":"en","type":"preprint","venue":"","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"","keywords":"Benzamide; RAD51; Sulfonyl; Transfection; Homologous recombination; Chemistry; Homologous chromosome; Stereochemistry; Molecular biology; Biology; Biochemistry; Gene; Organic chemistry; Alkyl","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002634178,0.0007309518,0.0002997652,0.0003711667,0.0002668951,0.0004807543,0.0004613318,0.0004355625,0.004745837],"category_scores_gemma":[0.0001482293,0.0003028868,0.0002871704,0.0002863502,0.0002994401,0.0002174544,0.0004558996,0.001009433,0.001793793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00062707,"about_ca_system_score_gemma":0.000325514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001641348,"about_ca_topic_score_gemma":0.002162973,"domain_scores_codex":[0.9997972,0.00002699703,0.00002398771,0.00005531427,0.00005084959,0.00004569318],"domain_scores_gemma":[0.999897,0.00002657692,0.00002378542,0.00001801367,0.000007843548,0.00002663295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074788,0.00002898803,0.00009306714,0.00006233073,0.00000625215,0.00005473655,0.00004577398,0.00005070353,0.9973808,0.0007269577,0.0001863466,0.001256463],"study_design_scores_gemma":[0.00004832333,0.00009331841,0.001476144,0.00001096674,0.00001746888,0.0001462873,0.00002671211,0.0006342106,0.9804771,0.00006921805,0.01699309,0.000007259052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9385335,0.001186659,0.03261344,0.0002881569,0.0004053531,0.0006387025,0.007858453,0.001043398,0.01743223],"genre_scores_gemma":[0.8979515,0.001079359,0.02519621,0.0001385147,0.0000450853,0.0005357021,0.0198381,0.000555525,0.05466012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004745837,"threshold_uncertainty_score":0.01587641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385628312007295,"score_gpt":0.3026311325199628,"score_spread":0.2887748493998898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}