{"id":"W3108111268","doi":"10.2337/db20-0474","title":"Loss of <i>Furin</i> in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction","year":2020,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; KU Leuven; Fonds Wetenschappelijk Onderzoek; Vlaamse regering; European Regional Development Fund; Deutsche Forschungsgemeinschaft","keywords":"Furin; mTORC1; Biology; Cell biology; Proprotein convertase; Proprotein Convertases; Endocrinology; Internal medicine; Signal transduction; PI3K/AKT/mTOR pathway; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757484,0.000556109,0.0003306142,0.0002706863,0.0001781468,0.0003795814,0.0002305461,0.0003137343,0.001526166],"category_scores_gemma":[0.00008720005,0.0002280348,0.000351893,0.0001863826,0.0003891466,0.0002423789,0.0002640782,0.0008322686,0.0005940498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003114295,"about_ca_system_score_gemma":0.0001767421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003048036,"about_ca_topic_score_gemma":0.0003038322,"domain_scores_codex":[0.9998067,0.00002753,0.00002730002,0.00005403241,0.0000389166,0.00004549082],"domain_scores_gemma":[0.9998299,0.0000182073,0.00007480413,0.00002066723,0.000007833937,0.00004844262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009937516,0.00001775733,0.0001260979,0.00001750892,0.00000530222,0.00007223887,0.00000578419,0.00002056941,0.9991161,0.00007019508,0.00002933554,0.000419682],"study_design_scores_gemma":[0.00002661561,0.0001635516,0.005438539,0.000007892117,0.00001793405,0.0006425082,0.00003120006,0.000453034,0.9905663,0.00008145618,0.002566475,0.000004495875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992009,0.0009624462,0.004007224,0.0001873824,0.00006327778,0.00003735932,0.000974015,0.0002028617,0.001556354],"genre_scores_gemma":[0.9934141,0.0006557319,0.002357351,0.0001349216,0.00001659832,0.00005025368,0.0009637433,0.00009470186,0.002312714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001526166,"threshold_uncertainty_score":0.005105555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311372181788595,"score_gpt":0.2352875448256765,"score_spread":0.2121738230077905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}