{"id":"W3108115150","doi":"10.1002/anie.202013302","title":"DNA Triplex and Quadruplex Assembled Nanosensors for Correlating K<sup>+</sup> and pH in Lysosomes","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Chemistry; Nanosensor; DNA; G-quadruplex; Biophysics; Nanotechnology; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008142024,0.0001350891,0.000129246,0.00002765844,0.00004503503,0.00003546006,0.00009139699,0.0001450742,0.00003330116],"category_scores_gemma":[0.0003095993,0.0001427701,0.00004889681,0.00004595998,0.00004126308,0.0000176962,0.00006831498,0.00008248264,0.000001756066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001865612,"about_ca_system_score_gemma":0.00002182298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005687399,"about_ca_topic_score_gemma":0.000002597651,"domain_scores_codex":[0.9991958,0.000009263569,0.0002018986,0.0003332579,0.0001179404,0.0001418793],"domain_scores_gemma":[0.999649,0.00004079132,0.00008111193,0.00007232311,0.00007324235,0.00008352575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001616264,0.00002547712,0.002153381,0.00004365423,0.00003953269,0.000002837339,0.0001899276,0.00002977657,0.989767,0.00003668537,0.006601338,0.0009487228],"study_design_scores_gemma":[0.001458167,0.00007610202,0.0006276465,0.00003031051,0.00001418071,0.00001364071,0.000335897,0.002236675,0.9782012,0.0001323541,0.01670865,0.000165178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955534,0.0002413203,0.000665062,0.001873002,0.0001160177,0.0001312982,0.00007332187,0.00001611471,0.00133048],"genre_scores_gemma":[0.9965979,0.0002260612,0.0005014334,0.000753867,0.0009929811,0.00003428564,0.0006530625,0.00001844811,0.0002219777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01156584,"threshold_uncertainty_score":0.5821996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.014607706972068,"score_gpt":0.2510163354079225,"score_spread":0.2364086284358544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}