{"id":"W3108186512","doi":"10.1158/2643-3230.bcd-20-0155","title":"Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; National Institute of General Medical Sciences; Medical Research Council; Canadian Institutes of Health Research; Canadian Cancer Society; Wellcome Trust","keywords":"Haematopoiesis; Myeloid leukemia; Myelopoiesis; Myeloid; Stem cell; Biology; Immunology; Cancer research; Leukemia; Regulator; Hematopoietic stem cell; Cell biology; Inflammation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001311112,0.0002877284,0.0003659986,0.00007475408,0.00009871056,0.00009773033,0.0002503439,0.0002104872,0.0001448323],"category_scores_gemma":[0.000009576311,0.0002750841,0.0000736776,0.0002417836,0.0001001987,0.0004400736,0.0002503045,0.0003439887,0.0001174356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001504026,"about_ca_system_score_gemma":0.0002001869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003309001,"about_ca_topic_score_gemma":0.0001379874,"domain_scores_codex":[0.9983439,0.00009238495,0.0004515244,0.0005361408,0.0000763253,0.0004996513],"domain_scores_gemma":[0.9994644,0.00002336112,0.0001784946,0.0002312354,0.00004514716,0.00005735063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005458056,0.0001192341,0.04759792,0.0003059424,0.0002631989,0.00001169928,0.002813788,0.0001985365,0.9227898,0.00004424618,0.001413963,0.02389589],"study_design_scores_gemma":[0.002760287,0.0002913082,0.01405123,0.0003257322,0.000117332,0.000005841234,0.0002863446,0.00002245453,0.9665451,0.00001093415,0.01511998,0.0004634398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884794,0.008414636,0.00005944523,0.0007188753,0.001187124,0.0009542326,0.0000521364,0.00008749263,0.00004666174],"genre_scores_gemma":[0.9968764,0.0007429945,0.00007501193,0.0005547364,0.0001222443,0.0003047052,0.00006194737,0.0000461791,0.001215753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04375535,"threshold_uncertainty_score":0.9999701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126590363725166,"score_gpt":0.2071703709343803,"score_spread":0.1945113345618636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}