{"id":"W3108250201","doi":"10.18632/aging.202236","title":"Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels","year":2020,"lang":"en","type":"article","venue":"Aging","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fujian Medical University","keywords":"PINK1; Parkin; Mitophagy; Mutant; Scaffold protein; Cell biology; Biology; Genetics; Gene; Medicine; Disease; Parkinson's disease; Signal transduction; Autophagy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577944,0.0002752109,0.0002667939,0.0002716374,0.000294007,0.0004720429,0.0001893199,0.0002878252,0.0010977],"category_scores_gemma":[0.0001832135,0.0001362125,0.0001793348,0.0001041553,0.0002838268,0.0003658806,0.0004108762,0.0002924203,0.0002541547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002194021,"about_ca_system_score_gemma":0.0001528966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003177525,"about_ca_topic_score_gemma":0.0005329687,"domain_scores_codex":[0.9998142,0.00002864641,0.00001323713,0.00004066497,0.0000558912,0.00004735867],"domain_scores_gemma":[0.9998682,0.0000181746,0.00003527013,0.00000963704,0.00002490779,0.0000438589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001281283,0.00001406369,0.001824563,0.00004458207,0.00001820925,0.0002203119,0.00005071931,0.00004112305,0.9937058,0.000528466,0.00006356739,0.003360475],"study_design_scores_gemma":[0.00001716067,0.0002493653,0.03947495,0.00001484393,0.00004089065,0.001210543,0.0001631986,0.001250177,0.9509295,0.0006185933,0.006017764,0.00001301991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865051,0.006023628,0.004691788,0.0002113951,0.00003525733,0.00001289639,0.0001111519,0.00008778107,0.002320939],"genre_scores_gemma":[0.9937991,0.001094275,0.002653715,0.00005065731,0.00001295231,0.00001617833,0.0001649364,0.00001421924,0.002193973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010977,"threshold_uncertainty_score":0.003672183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0309778302841409,"score_gpt":0.261523272843509,"score_spread":0.2305454425593681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}