{"id":"W3108312800","doi":"10.1186/s12884-020-03394-w","title":"Prenatal screening for trisomy 21: a comparative performance and cost analysis of different screening strategies","year":2020,"lang":"en","type":"article","venue":"BMC Pregnancy and Childbirth","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Newborn Screening Ontario; North York General Hospital; University of Toronto","funders":"","keywords":"Trisomy; Medicine; Cell-free fetal DNA; Down syndrome; Reproductive medicine; Prenatal screening; Obstetrics; Prenatal diagnosis; Aneuploidy; Genetic testing; Population; Gynecology; Pregnancy; Internal medicine; Chromosome; Psychiatry; Genetics; Fetus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006028324,0.0002166931,0.0006859624,0.0001216533,0.0001366205,0.00004172114,0.00007976821,0.00007480128,0.00001006596],"category_scores_gemma":[0.00008651762,0.0001777514,0.0001253455,0.0002806904,0.0001316753,0.0001830435,0.00008672677,0.0001624728,3.357467e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005055363,"about_ca_system_score_gemma":0.00003785511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001902401,"about_ca_topic_score_gemma":0.00002945299,"domain_scores_codex":[0.9988424,0.0000347292,0.0003264033,0.0003585276,0.0001872838,0.0002506754],"domain_scores_gemma":[0.9990622,0.0003262518,0.0001594465,0.0001541794,0.00006638761,0.0002314787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002308973,0.0001877255,0.9372478,0.001950432,0.001671074,0.000007033401,0.003592023,0.002049075,0.00007625799,0.001410961,0.0000763459,0.04942236],"study_design_scores_gemma":[0.004117016,0.0009423596,0.8689665,0.002299795,0.001397659,0.000009015838,0.001321146,0.1190587,0.001546375,0.00002355432,0.00007049826,0.0002474308],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8827132,0.004803246,0.1107867,0.0001003682,0.00001441961,0.0008130281,0.0002311238,0.0000627364,0.0004752325],"genre_scores_gemma":[0.9909885,0.0004181109,0.008145732,0.00009279534,0.00005192666,0.00005733173,0.0002100361,0.00001317655,0.0000224159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1170096,"threshold_uncertainty_score":0.7248491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05819313103048727,"score_gpt":0.2952407152883915,"score_spread":0.2370475842579042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}