{"id":"W3108312800","doi":"10.1186/s12884-020-03394-w","title":"Prenatal screening for trisomy 21: a comparative performance and cost analysis of different screening strategies","year":2020,"lang":"en","type":"article","venue":"BMC Pregnancy and Childbirth","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Newborn Screening Ontario; North York General Hospital; University of Toronto","funders":"","keywords":"Trisomy; Medicine; Cell-free fetal DNA; Down syndrome; Reproductive medicine; Prenatal screening; Obstetrics; Prenatal diagnosis; Aneuploidy; Genetic testing; Population; Gynecology; Pregnancy; Internal medicine; Chromosome; Psychiatry; Genetics; Fetus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003028804,0.0009647862,0.0009143209,0.00174636,0.0003093058,0.001344753,0.001335286,0.0009906867,0.003516195],"category_scores_gemma":[0.01176979,0.0003857274,0.001962542,0.001649891,0.0004607275,0.0009734028,0.0006226143,0.0005682413,0.00020792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009462856,"about_ca_system_score_gemma":0.002840664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.07185467,"about_ca_topic_score_gemma":0.03424668,"domain_scores_codex":[0.998058,0.0008739241,0.00009417224,0.0002318311,0.0003906243,0.0003513311],"domain_scores_gemma":[0.9882628,0.009086274,0.0009218638,0.0002640675,0.001180202,0.0002847245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.003638065,0.0006099813,0.08829388,0.000896936,0.001140266,0.0003606801,0.0001709661,0.8589341,0.001776045,0.00323748,0.00115891,0.0397827],"study_design_scores_gemma":[0.0006030913,0.005831192,0.1592794,0.000280054,0.002517606,0.0004536925,0.0007338875,0.8223162,0.002980999,0.002434633,0.002418382,0.0001508981],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864195,0.001765117,0.00417068,0.0004451866,0.00001962941,0.0002625248,0.002165966,0.00005793725,0.004693533],"genre_scores_gemma":[0.9964967,0.0005026074,0.001719892,0.00002479421,0.000004230962,0.00009866412,0.0006432669,0.000007882046,0.0005019073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07185467,"threshold_uncertainty_score":0.1428728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05819313103048727,"score_gpt":0.2952407152883915,"score_spread":0.2370475842579042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}