{"id":"W3108344241","doi":"10.1093/molbev/msaa298","title":"Frequent Assembly of Chimeric Complexes in the Protein Interaction Network of an Interspecies Yeast Hybrid","year":2020,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; Université Laval; PROTEO","funders":"British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Genome British Columbia; Canada Foundation for Innovation; Human Frontier Science Program","keywords":"Biology; Proteostasis; Saccharomyces cerevisiae; Phenotype; Protein–protein interaction; Yeast; Proteome; Genetics; Hybrid; Ploidy; Two-hybrid screening; Computational biology; Evolutionary biology; Gene; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633371,0.0000778585,0.0001130469,0.00002290675,0.00002761839,0.00000475465,0.0001399519,0.00006288537,0.000004386155],"category_scores_gemma":[0.00005503451,0.00005998108,0.00003956677,0.0001004832,0.0001526466,0.000003526863,0.00007567546,0.00009207038,9.522494e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006332295,"about_ca_system_score_gemma":0.00002505339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006401243,"about_ca_topic_score_gemma":0.00002853542,"domain_scores_codex":[0.9992236,0.0002349449,0.0001639589,0.000183569,0.00006215261,0.0001317526],"domain_scores_gemma":[0.9997145,0.00000573003,0.00006814601,0.0001270435,0.00005304956,0.00003156212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001706409,0.00004655335,0.002691938,0.00002092464,0.00001814647,0.000001471239,0.0000721073,0.0002546648,0.9948512,0.001098582,0.00004669217,0.0007270494],"study_design_scores_gemma":[0.0004092184,0.001818151,0.02710612,0.00002811559,0.00001160624,0.00001759615,0.0003573045,0.001567158,0.9667692,0.001063423,0.000730199,0.000121927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915879,0.0009273599,0.006769815,0.0003234703,0.00002893826,0.0001783629,0.00001422983,0.000002380368,0.0001674802],"genre_scores_gemma":[0.9992703,0.00003498759,0.0004218843,0.00009313138,0.00006970305,0.00001321929,0.0000874426,0.000005180926,0.00000412544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02808205,"threshold_uncertainty_score":0.2445958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01560043760908215,"score_gpt":0.2886446098004299,"score_spread":0.2730441721913477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}