{"id":"W3108410223","doi":"10.1186/s12974-020-02038-2","title":"Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment","year":2020,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre for Cognitive Ageing and Cognitive Epidemiology; University of Edinburgh; Alzheimer's Society; Alzheimer Society; Wellcome Trust; Biogen","keywords":"White matter; Pathology; Microglia; Medicine; Astrogliosis; Inflammation; Hyperintensity; Gliosis; Internal medicine; Central nervous system; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004803987,0.001683782,0.0008010493,0.001227072,0.0004458457,0.0005300152,0.0005411037,0.0009516091,0.001768161],"category_scores_gemma":[0.0001535807,0.0004930149,0.0006289479,0.000456831,0.0007324315,0.0005229381,0.0004480076,0.001689548,0.0004904552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005557365,"about_ca_system_score_gemma":0.0005568662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009179583,"about_ca_topic_score_gemma":0.001908509,"domain_scores_codex":[0.9996873,0.00003417567,0.00004208083,0.00007524562,0.00007480259,0.0000863889],"domain_scores_gemma":[0.9995414,0.00001484125,0.0001984211,0.0000352662,0.0000468889,0.0001631724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002038489,0.0008301237,0.001197121,0.0001906225,0.00006404271,0.0004075411,0.00009627933,0.000159022,0.9927004,0.0001559419,0.000194445,0.001965943],"study_design_scores_gemma":[0.0006840805,0.01427731,0.04575176,0.0002037879,0.0005057359,0.002697542,0.0003547581,0.00314491,0.9269695,0.0008293288,0.004507407,0.00007370539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943335,0.001386883,0.002210019,0.0002932341,0.00005768172,0.00007740125,0.0006417722,0.0002100163,0.0007893858],"genre_scores_gemma":[0.9871263,0.002272386,0.004314325,0.000246179,0.00004817204,0.0003957477,0.001180926,0.00005741499,0.00435859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001768161,"threshold_uncertainty_score":0.005915105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0365567233326073,"score_gpt":0.2507801439096042,"score_spread":0.2142234205769969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}