{"id":"W3108418196","doi":"10.1016/j.joca.2020.11.003","title":"Osteoarthritis year in review: genetics, genomics, epigenetics","year":2020,"lang":"en","type":"review","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Arthritis Society","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Epigenomics; Genomics; Biology; Non-coding RNA; Computational biology; DNA methylation; Genetics; microRNA; Long non-coding RNA; Human genetics; Bioinformatics; Gene; Genome; RNA; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002638843,0.0009717979,0.00399535,0.0002740867,0.0001059471,0.00009319609,0.000225212,0.0006241522,0.000252999],"category_scores_gemma":[0.00008660407,0.0009643839,0.000771054,0.0004701425,0.0001837336,0.00008600942,0.0002529172,0.0007589966,0.0005044999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001807349,"about_ca_system_score_gemma":0.0004686803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003240779,"about_ca_topic_score_gemma":0.0001293118,"domain_scores_codex":[0.9958568,0.0002320344,0.001435428,0.001218287,0.0004470754,0.0008103849],"domain_scores_gemma":[0.9980395,0.00006027632,0.0003553006,0.0007957129,0.00008968366,0.0006594665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002266671,0.00006023284,0.00002027059,0.01659724,0.00001313352,0.001798846,0.00006516033,1.366431e-8,0.0002141048,0.00006252392,0.0005331166,0.9806127],"study_design_scores_gemma":[0.002992258,0.00250355,0.000001282085,0.08097482,0.001229742,0.0009600243,0.0000446856,1.319668e-7,0.0002937701,0.00002912565,0.9102621,0.0007085008],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009576592,0.991544,8.395061e-7,0.0001807399,0.0004369488,0.00377571,0.0004298565,0.0001038519,0.002570412],"genre_scores_gemma":[0.0001344096,0.9962949,0.000422565,0.0006086685,0.0004935252,0.0004472637,0.0006272019,0.0002360442,0.0007354869],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9799042,"threshold_uncertainty_score":0.9992807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02110069456829079,"score_gpt":0.2779394165179687,"score_spread":0.2568387219496779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}