{"id":"W3108450721","doi":"10.1158/1538-7445.epimetab20-po-040","title":"Abstract PO-040: The role of mTOR in epigenetic regulation in cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"PI3K/AKT/mTOR pathway; mTORC1; Epigenetics; Biology; Cancer research; H3K4me3; Histone; Mechanistic target of rapamycin; Histone H3; Methylation; Histone methylation; Histone methyltransferase; Cell biology; DNA methylation; Biochemistry; Signal transduction; Gene expression; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001539769,0.0002605213,0.0002241209,0.0003261508,0.0002708513,0.00050458,0.0002456277,0.0003575812,0.004444833],"category_scores_gemma":[0.0001074484,0.0001018874,0.0002246651,0.0003385289,0.0002701987,0.0003012648,0.0002703822,0.0006374785,0.0009380544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000321242,"about_ca_system_score_gemma":0.0002935183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004138734,"about_ca_topic_score_gemma":0.0004711503,"domain_scores_codex":[0.9999195,0.00001197054,0.000007362694,0.00002165069,0.00002171732,0.00001780779],"domain_scores_gemma":[0.9999396,0.000006654958,0.00001655071,0.000004658626,0.00001523652,0.0000172857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008879887,0.00009122396,0.00226946,0.0005131027,0.00003734288,0.0003481636,0.00003404281,0.0003123427,0.9542629,0.001858128,0.001707087,0.0376782],"study_design_scores_gemma":[0.00008513539,0.0009977947,0.03909146,0.00008837379,0.00009934246,0.001365315,0.0001603681,0.002152025,0.8933592,0.001573011,0.06100513,0.00002286913],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8597031,0.08933252,0.009033131,0.004194014,0.0009629214,0.0002002882,0.003798459,0.0006087194,0.0321668],"genre_scores_gemma":[0.9669233,0.0145117,0.002836482,0.0005083957,0.0001455616,0.0000751498,0.001767331,0.00004967544,0.01318228],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.004444833,"threshold_uncertainty_score":0.01486945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0630443730385752,"score_gpt":0.3901539824734314,"score_spread":0.3271096094348562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}