{"id":"W3108451575","doi":"10.1080/15592294.2020.1834911","title":"DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the <i>RB1</i> gene promoter","year":2020,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Clinical Evaluative Sciences; Hospital for Sick Children; Public Health Ontario; University of Toronto; Impact","funders":"","keywords":"Biology; Epigenetics; DNA methylation; Genetics; Histone; Promoter; Molecular biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001064696,0.0001896615,0.0002646534,0.0006104059,0.0001846275,0.0001599793,0.0002370476,0.0002772501,0.002532023],"category_scores_gemma":[0.0003323434,0.0001782891,0.0002360536,0.0002150732,0.0004082754,0.0001170372,0.000264316,0.0004153777,0.0005346865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002048939,"about_ca_system_score_gemma":0.0001894466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001836472,"about_ca_topic_score_gemma":0.00159406,"domain_scores_codex":[0.9998555,0.00001996538,0.00001027666,0.00004299561,0.00004118885,0.00003005485],"domain_scores_gemma":[0.9997097,0.0000288864,0.00014966,0.00003380063,0.00001828839,0.00005969669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002222623,0.00001961904,0.003192185,0.00002127272,0.00001915075,0.0003934037,0.0000266632,0.00005032403,0.9943211,0.0001324689,0.00006625791,0.001535267],"study_design_scores_gemma":[0.00006141984,0.0003509043,0.2519308,0.00002224178,0.0001120401,0.01299028,0.0001597918,0.001336325,0.7293774,0.0004274744,0.003211754,0.00001956293],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957336,0.0008399126,0.001839846,0.00006083743,0.00001299224,0.00001329717,0.0003094976,0.0001069792,0.001083178],"genre_scores_gemma":[0.998359,0.0001550132,0.0004309705,0.00002436738,0.000004250167,0.00001011434,0.000300535,0.00001921998,0.0006964694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002532023,"threshold_uncertainty_score":0.008470476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008485247210636664,"score_gpt":0.2056338209144195,"score_spread":0.1971485737037828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}