{"id":"W3108655367","doi":"10.1200/jco.20.01762","title":"Lessons From ADAURA on Adjuvant Cancer Drug Trials: Evidence, Ethics, and Economics","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Cancer drugs; Drug; Adjuvant; Cancer; Drug trial; Oncology; Clinical trial; Internal medicine; Family medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1025424,0.001065553,0.003389904,0.002198738,0.002279333,0.009877117,0.002776818,0.0220659,0.01013574],"category_scores_gemma":[0.2550393,0.0007015965,0.001849753,0.002263081,0.01512064,0.01435581,0.004412017,0.01914337,0.001385226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007939736,"about_ca_system_score_gemma":0.01116249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005298126,"about_ca_topic_score_gemma":0.007404727,"domain_scores_codex":[0.9387861,0.04718272,0.002536169,0.002091605,0.007462481,0.001940817],"domain_scores_gemma":[0.5844256,0.3824091,0.008895988,0.007593591,0.01172414,0.004951641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003179404,0.0003212743,0.005422519,0.0029686,0.0009679224,0.0006940415,0.0008788032,0.004509212,0.0003963332,0.6050549,0.1881262,0.1874809],"study_design_scores_gemma":[0.00180994,0.0004050439,0.002796246,0.007935221,0.0006610436,0.0003393551,0.000795667,0.002073351,0.0005966521,0.7882764,0.1941749,0.0001362081],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0064035,0.0648521,0.003637272,0.8970929,0.0043293,0.00006676157,0.0002692812,0.00002996225,0.02331884],"genre_scores_gemma":[0.3126336,0.05976568,0.009801818,0.5891907,0.02309459,0.0004793131,0.0001783129,0.0001212245,0.004734706],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1025424,"threshold_uncertainty_score":0.5423024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4237922568072106,"score_gpt":0.5354944543091659,"score_spread":0.1117021975019553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}