{"id":"W3108664968","doi":"10.1101/2020.11.30.403543","title":"Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; European Commission; National Institutes of Health; amfAR, The Foundation for AIDS Research","keywords":"Epitope; Immunogenicity; Gp41; Neutralization; Virology; Antibody; Glycoprotein; Neutralizing antibody; Chemistry; Glycan; Trimer; Conformational epitope; Antigen; HIV vaccine; Biology; Virus; Human immunodeficiency virus (HIV); Biochemistry; Immunology; Vaccine trial; Dimer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001074783,0.0002903983,0.00009215299,0.0001359648,0.00006464279,0.0001962996,0.0001197776,0.0002207928,0.0004581742],"category_scores_gemma":[0.00007327147,0.00008840327,0.0001448596,0.00006061798,0.0001068848,0.0001177206,0.0001528604,0.0001992542,0.0001736979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872933,"about_ca_system_score_gemma":0.00009650933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006652263,"about_ca_topic_score_gemma":0.0009578395,"domain_scores_codex":[0.9999366,0.000008805337,0.000002849436,0.00001427267,0.00001887324,0.00001860218],"domain_scores_gemma":[0.9999667,0.000006009677,0.000007690469,0.000003900932,0.000006956073,0.000008694486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001462556,0.00001121444,0.00004609918,0.000006689469,0.000001252935,0.000008074967,0.000005207538,0.00008836295,0.9993424,0.00003050337,0.00001408999,0.0004313794],"study_design_scores_gemma":[0.000005505996,0.0001890798,0.0007693672,0.00000152259,0.000005694043,0.00004615626,0.000007081912,0.001948732,0.9965288,0.00001473311,0.0004813652,0.000001989689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940043,0.0002153852,0.004694625,0.00002322374,0.00001240396,0.00002619125,0.00004208942,0.00004479503,0.0009369409],"genre_scores_gemma":[0.9931718,0.0001529206,0.005114433,0.0000321276,0.000004408275,0.0000152135,0.00007550291,0.00001424083,0.001419299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006652263,"threshold_uncertainty_score":0.001532793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288601381879409,"score_gpt":0.2318337066318952,"score_spread":0.2189476928131011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}