{"id":"W3108705866","doi":"10.1002/ctm2.237","title":"Combinational therapy targeting the MET‐mTOR‐ROS loop disrupts mitochondrial autoregulatory machinery of liver cancer","year":2020,"lang":"en","type":"letter","venue":"Clinical and Translational Medicine","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"PI3K/AKT/mTOR pathway; Cancer research; Autophosphorylation; Oxidative phosphorylation; Mitochondrion; Cell biology; mTORC2; Mechanistic target of rapamycin; Phosphorylation; Biology; Chemistry; Signal transduction; mTORC1; Biochemistry; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003657709,0.0003198291,0.0005489882,0.00003978334,0.0001147786,0.00001013961,0.0003214972,0.0005876663,0.0004027328],"category_scores_gemma":[0.0002388107,0.0002069612,0.0002597422,0.00009485117,0.001202511,0.000005771391,0.00004453235,0.0009182303,0.000002293261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006820344,"about_ca_system_score_gemma":0.0002819589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004469792,"about_ca_topic_score_gemma":0.000005897297,"domain_scores_codex":[0.9974515,0.0002867427,0.0008578175,0.0005907575,0.0005987377,0.0002144792],"domain_scores_gemma":[0.9984508,0.000645637,0.0003489937,0.0002419951,0.0002158089,0.00009680832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005665825,0.0001118749,0.01177501,0.0002362064,0.001057668,0.00003741787,0.0001685965,0.00006339126,0.03306166,0.0002509627,0.9347263,0.01794431],"study_design_scores_gemma":[0.004802178,0.0009470343,0.01951508,0.0002698034,0.0003155787,0.00001142356,0.000007637895,0.000749969,0.001208397,0.001782508,0.9699001,0.000490258],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.08183762,0.05999697,0.0009934629,0.8495505,0.005358039,0.001064155,0.0008197143,0.00004155251,0.0003379233],"genre_scores_gemma":[0.4779932,0.006542405,0.0008909955,0.4458862,0.06282644,0.0001713846,0.004406469,0.0001525427,0.001130432],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4036644,"threshold_uncertainty_score":0.8439633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04817615481048524,"score_gpt":0.3411646388028844,"score_spread":0.2929884839923992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}