{"id":"W3108737232","doi":"10.1016/j.medj.2020.11.005","title":"The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19","year":2020,"lang":"en","type":"review","venue":"Med","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Janssen Biotech; UCB; Pfizer Australia; Bristol-Myers Squibb Canada; Gilead Sciences; Novartis; Eli Lilly and Company","keywords":"Medicine; Tumor necrosis factor alpha; Rheumatoid arthritis; Coronavirus disease 2019 (COVID-19); Repurposing; Immune system; Cytokine; Cytokine storm; Immunology; Observational study; Inflammation; Blockade; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Disease; Internal medicine; Infectious disease (medical specialty); Biology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001683307,0.0006892315,0.002270481,0.002523333,0.0002334684,0.001303241,0.0009705108,0.00152293,0.006603746],"category_scores_gemma":[0.002578377,0.0002464757,0.001477592,0.001858887,0.0004703762,0.001007099,0.0006429208,0.002161271,0.001060338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007812909,"about_ca_system_score_gemma":0.001798349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0017575,"about_ca_topic_score_gemma":0.004358021,"domain_scores_codex":[0.9996188,0.0001322473,0.00006761152,0.0000521621,0.00009558369,0.00003370945],"domain_scores_gemma":[0.9982629,0.001246755,0.0002259344,0.00002749627,0.0001757084,0.00006111647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004518486,0.0001018385,0.0002075752,0.09202992,0.0007678925,0.0002117864,0.00006229364,0.0002865185,0.001298147,0.004358083,0.01980708,0.8804171],"study_design_scores_gemma":[0.0005942733,0.0006685291,0.001657949,0.06332482,0.002770703,0.001529293,0.0001618855,0.0001900814,0.0008348792,0.003798422,0.9244106,0.00005852064],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005372853,0.9994961,0.00002221209,0.0001579573,0.00007064159,0.000003430985,0.00001334787,0.000001812783,0.0001807042],"genre_scores_gemma":[0.0007605183,0.9985555,0.00009598828,0.0003130699,0.00009064902,0.00000704713,0.00002559657,7.102682e-7,0.0001509503],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006603746,"threshold_uncertainty_score":0.02209175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2268555669508038,"score_gpt":0.5518468996274863,"score_spread":0.3249913326766826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}