{"id":"W3108737232","doi":"10.1016/j.medj.2020.11.005","title":"The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19","year":2020,"lang":"en","type":"review","venue":"Med","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Janssen Biotech; UCB; Pfizer Australia; Bristol-Myers Squibb Canada; Gilead Sciences; Novartis; Eli Lilly and Company","keywords":"Medicine; Tumor necrosis factor alpha; Rheumatoid arthritis; Coronavirus disease 2019 (COVID-19); Repurposing; Immune system; Cytokine; Cytokine storm; Immunology; Observational study; Inflammation; Blockade; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Disease; Internal medicine; Infectious disease (medical specialty); Biology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.001128826,0.0003471436,0.002024663,0.00005871922,0.0004816761,0.00003702475,0.0003645509,0.0001598471,0.0000254115],"category_scores_gemma":[0.03494946,0.0001372502,0.001794562,0.0002420032,0.000345074,0.00001175422,0.00007525891,0.0001990657,0.00000750134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003946982,"about_ca_system_score_gemma":0.002540563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009372194,"about_ca_topic_score_gemma":0.000009794554,"domain_scores_codex":[0.9976014,0.0002221709,0.0007916239,0.0004849758,0.0004876288,0.000412139],"domain_scores_gemma":[0.9568865,0.04139596,0.0004352629,0.0008033452,0.0002164576,0.0002624514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007410278,0.0001997031,0.000001570614,0.009027354,0.001998546,0.00001955834,0.0002010058,0.00000126476,0.000003171684,0.00008208314,0.002823482,0.9849012],"study_design_scores_gemma":[0.002890505,0.003069084,0.000004276003,0.001004408,0.001976339,0.000003953548,0.00005355088,0.0001134879,0.000009700654,0.0002122166,0.9905477,0.000114814],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002829804,0.9579874,0.00211091,0.02703999,0.0002924487,0.01236071,0.0001459675,0.00003690985,0.00002279288],"genre_scores_gemma":[0.00002077463,0.9919689,0.000172809,0.00114857,0.0008061695,0.004086563,0.00005890238,0.00005906729,0.001678205],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9877242,"threshold_uncertainty_score":0.9731796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2268555669508038,"score_gpt":0.5518468996274863,"score_spread":0.3249913326766826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}