{"id":"W3108869615","doi":"10.1101/2020.11.29.402990","title":"H3K4 trimethylation is required for postnatal pancreatic endocrine cell functional maturation","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; BC Children's Hospital","keywords":"Biology; Enteroendocrine cell; Islet; Endocrinology; Progenitor cell; Internal medicine; Endocrine system; Downregulation and upregulation; Pancreas; Cellular differentiation; Stem cell; Cell biology; Insulin; Gene; Hormone; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001360624,0.0001863187,0.0002044051,0.000237046,0.0001739739,0.0003177429,0.0002102919,0.0002001865,0.003682372],"category_scores_gemma":[0.0001686761,0.0001839416,0.0002203043,0.0001541677,0.0001984521,0.0001698099,0.0003332022,0.0004309285,0.001428701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433978,"about_ca_system_score_gemma":0.0002592737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009798594,"about_ca_topic_score_gemma":0.001190751,"domain_scores_codex":[0.9999061,0.00000673562,0.000006706367,0.0000296141,0.00002626701,0.00002467604],"domain_scores_gemma":[0.9998796,0.00001505914,0.00003076952,0.00002194589,0.00001526405,0.00003739606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001251846,0.000006855923,0.001430141,0.00003012529,0.000006233953,0.00006864563,0.00001528695,0.00004563078,0.9953023,0.0001071971,0.0001345776,0.002727653],"study_design_scores_gemma":[0.0000158509,0.00007624199,0.06452674,0.000008196435,0.00002187922,0.0003820602,0.00004421415,0.0008187842,0.9276773,0.0002111535,0.006211136,0.00000644505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816918,0.002883456,0.007447705,0.0002053159,0.00008264993,0.00002175708,0.00193346,0.0005431997,0.005190562],"genre_scores_gemma":[0.9807804,0.001247661,0.004470927,0.0001127025,0.00002352373,0.0000286512,0.003944262,0.0002236276,0.009168245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003682372,"threshold_uncertainty_score":0.01231879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02718748610850451,"score_gpt":0.2419605988097741,"score_spread":0.2147731127012696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}