{"id":"W3108920207","doi":"10.1093/ibd/izaa305","title":"Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK","year":2020,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa; McMaster University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Proinflammatory cytokine; Inflammation; AMPK; Tumor necrosis factor alpha; Autophagy; Myeloperoxidase; Medicine; Macrophage; Immunology; Inflammatory bowel disease; Protein kinase A; Kinase; Chemistry; Biology; Internal medicine; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007369059,0.0003423938,0.0003435654,0.00008362997,0.00017586,0.00008830814,0.0001853048,0.000104519,0.0007242181],"category_scores_gemma":[0.0004800114,0.0003189883,0.0001976388,0.00026443,0.0001540841,0.000402967,0.00007670412,0.0002617554,0.0003881683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007241961,"about_ca_system_score_gemma":0.0002159406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008118501,"about_ca_topic_score_gemma":4.771194e-7,"domain_scores_codex":[0.998148,0.00009021375,0.0005029071,0.0004417478,0.0004272559,0.0003898242],"domain_scores_gemma":[0.9984102,0.0001071056,0.0002456976,0.0003234137,0.0001473992,0.0007662387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004280729,0.0004943892,0.3123914,0.001675893,0.0006622709,0.002586619,0.002100327,0.0002338409,0.5955181,0.0008741962,0.03177848,0.04740375],"study_design_scores_gemma":[0.007093586,0.0007803477,0.6379338,0.00077029,0.0005527094,0.00006123661,0.0008701895,0.006924418,0.3041259,0.001312784,0.03814063,0.001434117],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943334,0.001617585,0.0002713109,0.001684347,0.00008980787,0.0005189009,0.00009802269,0.0006213275,0.0007652728],"genre_scores_gemma":[0.9960838,0.00009331154,0.0001793424,0.002339362,0.0007528983,0.00008049972,0.0002273236,0.00007287704,0.000170605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3255424,"threshold_uncertainty_score":0.9999262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335376104378105,"score_gpt":0.2576463380174055,"score_spread":0.2442925769736244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}