{"id":"W3108920603","doi":"10.3389/fonc.2020.573127","title":"Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy","year":2020,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Hubei University; Wuhan Municipal Science and Technology Bureau; Hubei University of Technology; Wuhan Science and Technology Project; National Natural Science Foundation of China; Xiamen University; Natural Science Foundation of Hubei Province; National Science Foundation","keywords":"Autophagy; AMPK; TRPM8; Cell biology; Transient receptor potential channel; ULK1; BAG3; Chemistry; Protein kinase A; AMP-activated protein kinase; Cancer research; Biology; Kinase; Receptor; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001922813,0.0001610118,0.0002838844,0.00007253361,0.0001351327,0.00002450576,0.0001697317,0.0001337518,0.00004686544],"category_scores_gemma":[0.00009938104,0.0001228135,0.00004168175,0.0003432716,0.0001428623,0.0001468007,0.00004412195,0.0002084904,0.000002659686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001038919,"about_ca_system_score_gemma":0.000108299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008054194,"about_ca_topic_score_gemma":0.00004048822,"domain_scores_codex":[0.9984205,0.0003021999,0.0003610821,0.0004365119,0.0002036925,0.0002760649],"domain_scores_gemma":[0.9994888,0.0000864264,0.0001962362,0.00006920424,0.0000532331,0.0001061294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000305709,0.00007844743,0.00003297091,0.00002687468,0.000005945937,0.000001586055,0.008348805,0.002065137,0.9454044,0.00001036262,0.02209857,0.02162115],"study_design_scores_gemma":[0.000363458,0.000366989,0.0001621095,0.00002761696,0.000005494695,0.000002440128,0.001005456,0.02493279,0.9688447,0.00003699999,0.004119982,0.0001319633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582689,0.0001347978,0.01719392,0.02105385,0.002368179,0.0007517034,0.0001610548,0.00002989168,0.00003765449],"genre_scores_gemma":[0.9962095,0.0002186784,0.001372035,0.001631793,0.0002528755,0.0001107425,0.00000772245,0.00001995884,0.0001766862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03794057,"threshold_uncertainty_score":0.5008188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035012418834789,"score_gpt":0.2550082389997517,"score_spread":0.2446581148114038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}