{"id":"W3108920603","doi":"10.3389/fonc.2020.573127","title":"Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy","year":2020,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Hubei University; Wuhan Municipal Science and Technology Bureau; Hubei University of Technology; Wuhan Science and Technology Project; National Natural Science Foundation of China; Xiamen University; Natural Science Foundation of Hubei Province; National Science Foundation","keywords":"Autophagy; AMPK; TRPM8; Cell biology; Transient receptor potential channel; ULK1; BAG3; Chemistry; Protein kinase A; AMP-activated protein kinase; Cancer research; Biology; Kinase; Receptor; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001218489,0.000227459,0.0004178904,0.0002341242,0.0002261209,0.0002393256,0.0001641268,0.0003244263,0.0008801831],"category_scores_gemma":[0.0001031931,0.0001127092,0.0003937261,0.0002019822,0.0001721525,0.000271294,0.0001706626,0.0006498109,0.0003649709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003538491,"about_ca_system_score_gemma":0.0002189213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004356277,"about_ca_topic_score_gemma":0.0005744447,"domain_scores_codex":[0.9998751,0.00001780819,0.00001344676,0.00002250451,0.00002257891,0.00004855003],"domain_scores_gemma":[0.9999596,0.000004232106,0.00001209299,0.0000042381,0.000007760641,0.00001219426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003759913,0.00007884442,0.0003058396,0.0001632272,0.00001116409,0.00008894091,0.00002312034,0.0001003228,0.9959393,0.0002010095,0.0002478794,0.002464325],"study_design_scores_gemma":[0.000112852,0.0004158834,0.00694895,0.00001299589,0.00005181931,0.000382668,0.00007238742,0.003198012,0.9803653,0.000169901,0.00825858,0.00001076651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987028,0.005753517,0.003783942,0.0004415653,0.0001414421,0.00005231747,0.0003963484,0.0003282017,0.002074682],"genre_scores_gemma":[0.9938509,0.001996432,0.001690555,0.0001576204,0.00002103207,0.00008786408,0.0004102273,0.0000189831,0.001766242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008801831,"threshold_uncertainty_score":0.002944529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035012418834789,"score_gpt":0.2550082389997517,"score_spread":0.2446581148114038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}