{"id":"W3108955097","doi":"10.1101/2020.11.23.394270","title":"Membrane-tethered peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as allosteric biased ligands","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; McGill University; Institut National de la Recherche Scientifique","funders":"Faculty of Medicine and Health, University of Sydney; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada; McGill University; Faculty of Medicine, McGill University; Natural Sciences and Engineering Research Council of Canada","keywords":"Allosteric regulation; Intracellular; Receptor; Signal transduction; Urotensin-II; Allosteric modulator; Phosphorylation; Biology; Cell biology; Chemistry; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005205761,0.0007286937,0.001455477,0.0002161338,0.000236338,0.0001457622,0.0006433895,0.0005146385,0.0002124568],"category_scores_gemma":[0.001656179,0.0005928891,0.0006278628,0.0006479835,0.0005857791,0.0001043138,0.001610768,0.001496396,0.00005329946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001356467,"about_ca_system_score_gemma":0.0008900829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003823484,"about_ca_topic_score_gemma":0.000005427117,"domain_scores_codex":[0.9958187,0.0004632587,0.0007400562,0.0013699,0.001038604,0.0005694541],"domain_scores_gemma":[0.9959764,0.0002201765,0.0004685183,0.002017315,0.000784643,0.0005329881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004671593,0.0001387411,0.00391882,0.0006998136,0.001186157,0.0002108316,0.00008550008,0.000009804526,0.9929378,0.000009051231,0.0003178866,0.00001841303],"study_design_scores_gemma":[0.001720347,0.000211139,0.09779701,0.001189673,0.0005519279,1.933301e-7,0.00001880521,0.0001242083,0.8933883,0.000001280225,0.00451585,0.0004812568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927554,0.003238661,0.00006210266,0.001114973,0.0005075487,0.001665653,0.0004632527,0.0001624467,0.00002996482],"genre_scores_gemma":[0.9950035,0.002483953,0.00120289,0.0004076551,0.00061506,0.00004649413,0.000003545603,0.000206951,0.00002999385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09954952,"threshold_uncertainty_score":0.9996523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02403719184681495,"score_gpt":0.2375734039971297,"score_spread":0.2135362121503147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}