{"id":"W3108955097","doi":"10.1101/2020.11.23.394270","title":"Membrane-tethered peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as allosteric biased ligands","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; McGill University; Institut National de la Recherche Scientifique","funders":"Faculty of Medicine and Health, University of Sydney; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada; McGill University; Faculty of Medicine, McGill University; Natural Sciences and Engineering Research Council of Canada","keywords":"Allosteric regulation; Intracellular; Receptor; Signal transduction; Urotensin-II; Allosteric modulator; Phosphorylation; Biology; Cell biology; Chemistry; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009158521,0.0001819926,0.0001053508,0.00003813902,0.00005168646,0.0001422764,0.0001202941,0.0001724931,0.0009592646],"category_scores_gemma":[0.00007308299,0.00005005414,0.000116228,0.00004188953,0.0001430555,0.0001278828,0.0001285138,0.0002580713,0.0001445055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001321537,"about_ca_system_score_gemma":0.00007170084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001154065,"about_ca_topic_score_gemma":0.0001752979,"domain_scores_codex":[0.9999617,0.000009140592,0.000002615148,0.000005897548,0.000007339911,0.00001322963],"domain_scores_gemma":[0.9999633,0.000009365065,0.00001125203,0.000003147831,0.000002894828,0.00001008048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007391997,0.00001148742,0.00007464553,0.00001712234,0.000001866872,0.00003948038,0.000006087938,0.0001087051,0.9992326,0.0000805174,0.00001058337,0.0003427849],"study_design_scores_gemma":[0.00002380049,0.0003500692,0.0008634864,0.000004151068,0.00000619075,0.0001259518,0.00001551479,0.001213325,0.9964494,0.00003032565,0.0009140663,0.000003787062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980282,0.0003210292,0.001055781,0.00003077503,0.00001157094,0.00001432061,0.00004262279,0.00001115723,0.0004845259],"genre_scores_gemma":[0.9980764,0.0001802686,0.00113203,0.00004197694,0.000003150475,0.000009147144,0.00005414815,0.000003415262,0.000499364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009592646,"threshold_uncertainty_score":0.003209114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02403719184681495,"score_gpt":0.2375734039971297,"score_spread":0.2135362121503147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}