{"id":"W3109013868","doi":"10.1002/acn3.51249","title":"Brain volumetric deficits in <i>MAPT</i> mutation carriers: a multisite study","year":2020,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; Canadian Institutes of Health Research; Parkinsonfonden; University of California, San Diego; Genentech; Allergan; National Institutes of Health; Pfizer; Biogen; Alzheimer Nederland; Stichting Dioraphte; Eisai; Puma Biotechnology; Novartis; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Roche; Janssen Pharmaceuticals; Erasmus Universiteit Rotterdam; BrightFocus Foundation; Eli Lilly and Company; Bristol-Myers Squibb; Parkinson Study Group; AbbVie; TauRx Pharmaceuticals; Sol Goldman Charitable Trust; Alzheimer's Association; ZonMw; Michael J. Fox Foundation for Parkinson's Research","keywords":"Frontotemporal dementia; Medicine; White matter; Atrophy; Parkinsonism; Pathology; Uncinate fasciculus; Dementia; Frontotemporal lobar degeneration; Magnetic resonance imaging; Disease; Fractional anisotropy; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005535774,0.0007151271,0.0004306809,0.0009485671,0.0005685496,0.000409552,0.0003625808,0.000608968,0.001328588],"category_scores_gemma":[0.001618715,0.0003276324,0.0003684256,0.0004416464,0.0004910734,0.000437199,0.0005425559,0.0003030237,0.0002834955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236141,"about_ca_system_score_gemma":0.0001394508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003000392,"about_ca_topic_score_gemma":0.002972096,"domain_scores_codex":[0.99976,0.00004996985,0.00003061706,0.00008370307,0.00004405011,0.00003165998],"domain_scores_gemma":[0.9993078,0.0001255214,0.0002975786,0.00005671068,0.00008668301,0.0001257065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001094368,0.0002832545,0.9810379,0.0000225436,0.0002167552,0.001748392,0.0007314738,0.0001225246,0.01127285,0.00003961271,0.0001365282,0.0032938],"study_design_scores_gemma":[0.00003186481,0.0005396359,0.9962015,0.000004019552,0.00005554459,0.002235346,0.0001650875,0.0002127292,0.0004177793,0.00002584599,0.0001034086,0.000007217387],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998436,0.00001542541,0.00003368663,0.000003565104,6.84186e-7,0.000004450846,0.00004255385,0.000001785687,0.00005417061],"genre_scores_gemma":[0.9997084,0.00001304163,0.00007496285,0.000006294443,0.000003538514,0.000007391091,0.0001091952,0.000003347116,0.0000739276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003000392,"threshold_uncertainty_score":0.005965829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2240546808260397,"score_gpt":0.4482847500131946,"score_spread":0.2242300691871549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}