{"id":"W3109045415","doi":"10.1038/s41467-020-19876-6","title":"Cohesin depleted cells rebuild functional nuclear compartments after endomitosis","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Deutsche Forschungsgemeinschaft; Ludwig-Maximilians-Universität München; International Max Planck Research School for Advanced Methods in Process and Systems Engineering; International Max Planck Research School for Environmental, Cellular and Molecular Microbiology; U.S. Department of Agriculture; Deutsches Krebsforschungszentrum; Welch Foundation; Institute of Genetics; National Institutes of Health; National Science Foundation","keywords":"Cohesin; Chromatin; Cell biology; Biology; Cell nucleus; Replication timing; CTCF; Chromosome segregation; Chromosome; Nucleus; Genetics; DNA; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004203571,0.0001169981,0.0001062958,0.00001754164,0.0001454049,0.00003155159,0.0005480857,0.0002219702,0.0000440728],"category_scores_gemma":[0.00004115159,0.0001226351,0.0000903468,0.00009080998,0.00007136433,0.000003077869,0.0004132732,0.000328196,0.00005768177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001618254,"about_ca_system_score_gemma":0.00003388341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002960034,"about_ca_topic_score_gemma":0.0000562254,"domain_scores_codex":[0.9993333,0.0000709121,0.0001661936,0.0002081302,0.00009192181,0.0001296007],"domain_scores_gemma":[0.9988489,0.00002242477,0.00006943233,0.0008859956,0.00007883579,0.00009442928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002095639,0.0002357144,0.005262021,0.00001586046,0.000205822,0.000001435714,0.000137757,0.0001153301,0.9135942,0.001619838,0.07817932,0.000423146],"study_design_scores_gemma":[0.001423336,0.0001596718,0.02282606,0.00001189545,0.00008739201,0.000008597204,0.0001479332,0.0052231,0.02371196,0.00009351258,0.9458736,0.0004330067],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808822,0.004129321,0.0004119457,0.009413456,0.0002488319,0.0003694737,0.0002634032,0.00005831666,0.004223091],"genre_scores_gemma":[0.9862694,0.0004007519,0.008049281,0.004497079,0.0001058492,0.00002752951,0.0005804177,0.00002606492,0.00004360552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8898822,"threshold_uncertainty_score":0.5000916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01313016377613391,"score_gpt":0.231450335876093,"score_spread":0.2183201720999591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}