{"id":"W3109088591","doi":"10.1021/acschemneuro.0c00445","title":"Furosemide as a Probe Molecule for the Treatment of Neuroinflammation in Alzheimer’s Disease","year":2020,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canada Research Chairs","keywords":"Neuroinflammation; Proinflammatory cytokine; Microglia; Downregulation and upregulation; Unfolded protein response; Neurodegeneration; Pharmacology; Chemistry; Cell biology; Immunology; Inflammation; Medicine; Biology; Endoplasmic reticulum; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001969122,0.0002577561,0.0002664319,0.0002976529,0.0001612483,0.0001742852,0.0001980405,0.0003300756,0.0007786271],"category_scores_gemma":[0.0000837846,0.00007911397,0.0001885337,0.0002260851,0.0002046095,0.0002218811,0.0001582934,0.0005619585,0.0002053332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000265335,"about_ca_system_score_gemma":0.0002236297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006017109,"about_ca_topic_score_gemma":0.001001626,"domain_scores_codex":[0.9999353,0.00002196344,0.000005396774,0.000009290261,0.00001512472,0.0000129201],"domain_scores_gemma":[0.9999702,0.000005499389,0.000008305596,0.000003169052,0.000006336861,0.000006524398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001599476,0.0006386962,0.0004941832,0.00108014,0.00006343423,0.0006128833,0.0001146591,0.0005104436,0.8776386,0.002625377,0.001898863,0.1127232],"study_design_scores_gemma":[0.0005925066,0.007137319,0.0069401,0.0002056244,0.0001653392,0.002761993,0.00007582828,0.001165734,0.8702169,0.0009880224,0.1097017,0.00004888391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4952621,0.4761944,0.01470452,0.002367351,0.000593271,0.0002166003,0.0004987186,0.0002109135,0.009952058],"genre_scores_gemma":[0.861535,0.1211962,0.0105576,0.0005682086,0.0002029841,0.0001309725,0.0003947755,0.00001652275,0.005397768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007786271,"threshold_uncertainty_score":0.002604723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07729973776889328,"score_gpt":0.2985302388688747,"score_spread":0.2212305010999814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}