{"id":"W3109103430","doi":"10.1101/2020.11.29.402800","title":"Mapping the Cellular Origin and Early Evolution of Leukemia in Down Syndrome","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; SickKids Foundation; University Health Network; University of Toronto; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"","keywords":"Preleukemia; Biology; GATA1; Leukemia; Stem cell; Haematopoiesis; Trisomy; Cancer research; Myeloid leukemia; Progenitor cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009478673,0.0001356677,0.00009771372,0.0004635493,0.0001123033,0.0001821951,0.00007935319,0.0001593498,0.001397835],"category_scores_gemma":[0.0001230781,0.0001258263,0.0001288344,0.0001781413,0.0001130567,0.00009400828,0.0002043892,0.000216114,0.0002960189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001525847,"about_ca_system_score_gemma":0.00007956929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008490434,"about_ca_topic_score_gemma":0.0007335973,"domain_scores_codex":[0.9999493,0.000008247236,0.000004695971,0.00001549625,0.00001019621,0.00001202202],"domain_scores_gemma":[0.9999274,0.00002641314,0.00001719349,0.000007929951,0.000005798833,0.00001527827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001689225,0.000008620625,0.012132,0.00002324778,0.000006708027,0.000267217,0.00004268367,0.00007532877,0.9838687,0.0002717232,0.00004040353,0.003094492],"study_design_scores_gemma":[0.00002305691,0.0003120413,0.285247,0.00002362265,0.00005623129,0.005152818,0.0001366114,0.001561504,0.6990761,0.0003434937,0.008058283,0.000009187809],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941005,0.0006478059,0.00345795,0.00002858941,0.000006010907,0.00001557312,0.0007297668,0.00003229166,0.0009813285],"genre_scores_gemma":[0.9942819,0.0006858181,0.003006683,0.00002249812,0.000003266326,0.00001290805,0.0008936297,0.00001925273,0.001074125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001397835,"threshold_uncertainty_score":0.004676282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02443526448122609,"score_gpt":0.2381785022708749,"score_spread":0.2137432377896488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}