{"id":"W3109153699","doi":"10.1101/2020.11.23.20235515","title":"Excess Dietary Fructose Does Not Alter Gut Microbiota or Permeability in Humans: A Randomized Controlled Pilot Study","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; U.S. Department of Health and Human Services; National Institutes of Health; Georgia Clinical and Translational Science Alliance; NHLBI Division of Intramural Research; York University; American Heart Association","keywords":"Fructose; Metabolome; Gut flora; Fatty liver; Internal medicine; Intestinal permeability; Endocrinology; Microbiome; Butyrate; Metabolic syndrome; Biology; Uric acid; Physiology; Medicine; Obesity; Biochemistry; Disease; Metabolite; Bioinformatics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006617891,0.002268128,0.00500926,0.0008238393,0.001236021,0.00137386,0.001195107,0.003265866,0.007056435],"category_scores_gemma":[0.004353326,0.001170714,0.002312351,0.0009190938,0.003725413,0.00181542,0.0009466666,0.002337183,0.000739431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008888274,"about_ca_system_score_gemma":0.002571009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001214956,"about_ca_topic_score_gemma":0.001848193,"domain_scores_codex":[0.996224,0.002291781,0.0002881441,0.0005104712,0.0002148335,0.0004708048],"domain_scores_gemma":[0.9964579,0.0008858229,0.0008045298,0.0004788556,0.0003265452,0.001046342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.974935,0.01851673,0.0005941208,0.0003552045,0.000549206,0.0000321143,0.00003623571,0.00006012159,0.001446796,0.00003397936,0.0001725308,0.003267903],"study_design_scores_gemma":[0.7324114,0.2637477,0.002119806,0.00003225489,0.0006800903,0.00001654652,0.00003758026,0.00015502,0.0003333081,0.00008886034,0.0003574429,0.0000200006],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785446,0.001938683,0.001280744,0.0004904149,0.0009011889,0.01544213,0.000580023,0.000112089,0.0007101909],"genre_scores_gemma":[0.967225,0.001808684,0.003658872,0.00113449,0.001122742,0.02249624,0.0005663316,0.00002750026,0.001960083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007056435,"threshold_uncertainty_score":0.03499913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05336626602462206,"score_gpt":0.3271625284134609,"score_spread":0.2737962623888388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}