{"id":"W3109158687","doi":"10.1158/2643-3249.lymphoma20-po-04","title":"Abstract PO-04: Noncoding mutations in mantle cell lymphoma disrupt regulation of HNRNPH1 by alternative splicing","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Minigene; RNA splicing; Biology; Exonic splicing enhancer; Exon; Intron; Alternative splicing; Genetics; Exon skipping; Splicing factor; Silent mutation; Nonsense-mediated decay; Mutation; Cancer research; Molecular biology; RNA; Gene; Missense mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007221126,0.0001125167,0.0001420962,0.00003748181,0.00006377749,0.00002689209,0.0001406203,0.00005979189,0.00001638077],"category_scores_gemma":[0.00003061704,0.0001124025,0.00006425632,0.0001302384,0.00004387096,0.00002663566,0.00009275357,0.00006094923,0.000002449022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002843686,"about_ca_system_score_gemma":0.0001140308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009465291,"about_ca_topic_score_gemma":0.000233945,"domain_scores_codex":[0.999081,0.00002523092,0.000224989,0.0002846851,0.0001701098,0.0002140039],"domain_scores_gemma":[0.999619,0.00001805838,0.0001136811,0.0001387678,0.00003686464,0.00007362419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000883274,0.0001039899,0.009155273,0.0000755822,0.00003653339,0.000005229492,0.00021716,0.001523965,0.9870226,0.00001562627,0.0002263028,0.001529419],"study_design_scores_gemma":[0.001397255,0.000117561,0.02268467,0.00006365844,0.00001868733,0.000001179309,0.0002548708,0.0007119532,0.9743016,0.00002941469,0.0002780324,0.0001411208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964938,0.001055107,0.0007724345,0.0002601559,0.00004096061,0.0001571171,0.000132632,0.000004871597,0.001082904],"genre_scores_gemma":[0.9986582,0.0003350255,0.00007725422,0.0001291223,0.0001488508,0.00002660711,0.0001293209,0.00001877506,0.0004768007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0135294,"threshold_uncertainty_score":0.4583641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01310041543215035,"score_gpt":0.2738839860172324,"score_spread":0.260783570585082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}