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Università degli Studi di Verona; Khalifa University of Science, Technology and Research; Pennsylvania State University; Lunds Universitet; Horizon 2020 Framework Programme; Universiteit Utrecht; Medical Research Council; Servier; University of Bristol; Imperial College London; National Human Genome Research Institute; Kidney Research UK; Department of Health and Social Care; University of Cambridge; British Heart Foundation; Stichting de Drie Lichten; Isaac Newton Trust; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Barts Charity; U.S. Department of Health and Human Services; Genomic Health; Vanderbilt University Medical Center; National Cancer Institute; University College London; Cancer Research UK; Wellcome Trust; Gentofte Hospital; National Institute for Health and Care Research; University of North Carolina at Chapel Hill; Queen Mary University of London; Pfizer; University of Washington; National Institute on Minority Health and Health Disparities; AstraZeneca; Genentech; School of Public Health, Imperial College London; University of Oxford; Amgen; Novo Nordisk; Li Ka Shing Foundation; School of Medicine, Boston University; Cambridge University Hospitals; University of Pennsylvania; Vanderbilt University; International Seafood Sustainability Foundation; Biogen; Government of the United Kingdom; University of Michigan; UK Research and Innovation; Eli Lilly and Company","keywords":"Biology; Meta-analysis; Computational biology; Genetics; Blood pressure; Evolutionary biology; Bioinformatics; Internal medicine; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0004443746,0.0004934957,0.003693743,0.000177972,0.00004877474,0.00001596147,0.0004636843,0.002090458,0.0000284641],"category_scores_gemma":[0.000602144,0.0003578384,0.001876832,0.00114362,0.0001039592,0.000005115134,0.0001897314,0.0004555803,6.2615e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001079292,"about_ca_system_score_gemma":0.0002985066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007992025,"about_ca_topic_score_gemma":0.00003260949,"domain_scores_codex":[0.996867,0.00066817,0.001070869,0.0007199214,0.0003993289,0.0002747323],"domain_scores_gemma":[0.9964507,0.0001724157,0.002158654,0.0007924332,0.0003747311,0.00005106973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00002466923,0.000327957,0.002523982,0.002256522,0.9835151,0.000003944113,0.0001337693,0.001845672,0.0002621385,0.00007832161,0.001968161,0.007059714],"study_design_scores_gemma":[0.0002708103,0.0003352484,0.004160829,0.0001634076,0.7741023,0.000004297847,0.000009472316,0.00002936641,0.0004248226,0.00008465885,0.2200075,0.0004072945],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001062695,0.9941537,0.0006455234,0.0000368982,0.00007682731,0.0005736842,0.003320181,0.000007109705,0.0001233941],"genre_scores_gemma":[0.04059005,0.9486207,0.003425452,0.00007943573,0.0001067624,0.00004557571,0.006685155,0.0000614272,0.0003854313],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2180394,"threshold_uncertainty_score":0.9998873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04167368506031807,"score_gpt":0.3203020398534679,"score_spread":0.2786283547931498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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