{"id":"W3109220255","doi":"10.3389/fimmu.2020.604142","title":"Metabolic Vulnerabilities and Epigenetic Dysregulation in Myeloproliferative Neoplasms","year":2020,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Epigenetics; Cancer research; Biology; Myelopoiesis; Haematopoiesis; Myeloid; Phenotype; Stem cell; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002154098,0.0002124868,0.0002116439,0.0002229397,0.0001360286,0.0003662879,0.0001773906,0.0004101596,0.0008550835],"category_scores_gemma":[0.0001475965,0.00007617981,0.0001013057,0.0001521736,0.0004293642,0.0002797326,0.0003041,0.0005792906,0.0001693389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003017667,"about_ca_system_score_gemma":0.0002070183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001255253,"about_ca_topic_score_gemma":0.0002497847,"domain_scores_codex":[0.9999261,0.00001681188,0.000003484586,0.00001380778,0.00002560793,0.00001417073],"domain_scores_gemma":[0.9999247,0.0000215515,0.00002436615,0.000002596792,0.00001007711,0.00001668229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000632257,0.00016462,0.009526224,0.002143136,0.00006724409,0.003101456,0.0004506496,0.0011914,0.4976855,0.03151357,0.01625717,0.4372669],"study_design_scores_gemma":[0.00010817,0.001021027,0.09381527,0.0007334799,0.000191999,0.02314226,0.0007978237,0.003535568,0.181958,0.04054763,0.6540698,0.0000789868],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2363698,0.7055504,0.01553062,0.01781228,0.001196599,0.00007091369,0.0004940446,0.0003473837,0.02262797],"genre_scores_gemma":[0.7124109,0.2715703,0.004548831,0.002215898,0.001634788,0.0000734274,0.0002357009,0.00002584559,0.007284306],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0008550835,"threshold_uncertainty_score":0.002860546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02249860134037886,"score_gpt":0.2941017163203433,"score_spread":0.2716031149799644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}