{"id":"W3109236711","doi":"10.3389/fnmol.2020.601102","title":"A Functional Comparison of Homopentameric Nicotinic Acetylcholine Receptors (ACR-16) Receptors From Necator americanus and Ancylostoma ceylanicum","year":2020,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Parasite Biology and Host Interactions","field":"Environmental Science","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Necator americanus; Pharmacology; Biology; Nicotinic agonist; Acetylcholine receptor; Pyrantel; Acetylcholine; Agonist; Receptor; Partial agonist; Anthelmintic; Biochemistry; Immunology; Zoology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009667752,0.0001867665,0.0003261779,0.00006740338,0.000105425,0.00001909204,0.0003846803,0.00007466865,0.0003539511],"category_scores_gemma":[0.0002043461,0.0001885074,0.00005657736,0.0006675693,0.00083012,0.0002217481,0.0002376788,0.0003017632,0.00006134799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008524201,"about_ca_system_score_gemma":0.00002228749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002058987,"about_ca_topic_score_gemma":0.0000275819,"domain_scores_codex":[0.9982312,0.0001734467,0.0003488411,0.0006756824,0.0002739042,0.0002969447],"domain_scores_gemma":[0.9993105,0.00004867405,0.0002112234,0.0002244004,0.000007330279,0.0001978626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001112887,0.0001460089,0.7552547,0.000003754627,0.000007107441,0.000006778298,0.0004430617,0.000553543,0.2163759,0.000009962178,0.01439891,0.01268896],"study_design_scores_gemma":[0.0009873859,0.0008395491,0.8094912,0.00002831173,0.00004845367,0.00001658049,0.001478107,0.00991765,0.06953385,0.0001076019,0.1069073,0.0006439934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808843,0.0006565621,0.01485094,0.0009340047,0.001796836,0.0002055518,0.00003216826,0.00003399198,0.0006056574],"genre_scores_gemma":[0.9932584,0.0002199822,0.004595764,0.001769436,0.00002590324,0.00001405509,0.0000229213,0.00001438979,0.0000791428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.146842,"threshold_uncertainty_score":0.768711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725619726785725,"score_gpt":0.2865651562436952,"score_spread":0.2693089589758379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}