{"id":"W3109322209","doi":"10.33380/2305-2066-2020-9-4-146-154","title":"Development and Validation of Pomalidomide Determination in Human Plasma by HPLC-MS/MS Method","year":2020,"lang":"en","type":"article","venue":"Drug development & registration","topic":"Analytical Methods in Pharmaceuticals","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Public Health Association","funders":"","keywords":"Pomalidomide; Protein precipitation; Chromatography; High-performance liquid chromatography; Detection limit; Multiple myeloma; Chemistry; Pharmacokinetics; Thalidomide; Pharmacology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001044388,0.0002413787,0.0003392037,0.00008621718,0.000107213,0.00005419536,0.0001820239,0.0001454419,0.0002125531],"category_scores_gemma":[0.0004097673,0.0002607064,0.00003457301,0.000232069,0.00007071283,0.000225429,0.0000791463,0.0002200219,0.000007597683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001983107,"about_ca_system_score_gemma":0.0001549002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001385958,"about_ca_topic_score_gemma":0.0000141402,"domain_scores_codex":[0.9976379,0.0001318339,0.001020794,0.0004869123,0.0004713265,0.0002511994],"domain_scores_gemma":[0.9990135,0.0002117871,0.000374926,0.0001487359,0.0000898165,0.0001612724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001072463,0.0001695594,0.004679282,0.0006178381,0.00005072273,0.00001025561,0.005612371,0.00004737249,0.8746197,0.001914581,0.000413849,0.1117572],"study_design_scores_gemma":[0.0008224039,0.000007424422,0.000713677,0.0000858858,0.00002505181,0.0000036338,0.0002472563,0.004996512,0.9792817,0.0002700036,0.01325878,0.0002877305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9336476,0.00004028541,0.05798062,0.0006100924,0.00003070707,0.0002166409,0.000005509713,0.00006818825,0.007400337],"genre_scores_gemma":[0.6111955,0.000009232339,0.3879651,0.00008874716,0.00003720316,0.00004771031,0.0001619472,0.00002194213,0.0004726132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3299845,"threshold_uncertainty_score":0.9999845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06006610392576663,"score_gpt":0.3667722658832706,"score_spread":0.3067061619575039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}