{"id":"W3109359388","doi":"10.1126/sciadv.abd1327","title":"Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Parkinsonfonden; National Institutes of Health; IXICO; H. Lundbeck A/S; Knut och Alice Wallenbergs Stiftelse; Servier; Skånes universitetssjukhus; Vetenskapsrådet; Eisai; Lunds Universitet; Svenska Forskningsrådet Formas; NIH Clinical Center; F. Hoffmann-La Roche; Australian Government; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; Janssen Alzheimer Immunotherapy Research And Development; Hjärnfonden; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; Genentech; Marcus och Amalia Wallenbergs minnesfond; Avid Radiopharmaceuticals; Parkinson Research Foundation; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Tau pathology; Disease; Pathology; Alzheimer's disease; Medicine; Neuroscience; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001399871,0.0006096985,0.000563345,0.0008151341,0.0002573863,0.0004977775,0.0005014443,0.0007434949,0.0009494007],"category_scores_gemma":[0.006010378,0.0002968993,0.0005896954,0.0004156871,0.0003483699,0.0007769776,0.0004445024,0.0006815662,0.0001873056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000475022,"about_ca_system_score_gemma":0.000439626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005277027,"about_ca_topic_score_gemma":0.008791151,"domain_scores_codex":[0.9996717,0.0001761726,0.00001422223,0.00008582431,0.00002834972,0.00002375454],"domain_scores_gemma":[0.9981306,0.001234512,0.0002846089,0.000121361,0.0001315162,0.00009740942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0009652398,0.0002105048,0.08839977,0.0001530221,0.0004497835,0.0005169489,0.0003279966,0.8259888,0.007725079,0.005151239,0.001834485,0.06827707],"study_design_scores_gemma":[0.00002177121,0.0001361669,0.01760156,0.00001669889,0.00005710271,0.0002314615,0.00002211868,0.9753862,0.0008871522,0.005296147,0.0003226877,0.00002103229],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7437858,0.0007746176,0.2521673,0.0005132233,0.00004736761,0.0001133013,0.0009821025,0.0003876518,0.001228697],"genre_scores_gemma":[0.9814248,0.0001849919,0.01727517,0.00004842455,0.00002236022,0.00007028817,0.0004957588,0.00002222533,0.0004559113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005277027,"threshold_uncertainty_score":0.01049262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04359039739783836,"score_gpt":0.330661865838831,"score_spread":0.2870714684409926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}