{"id":"W3109359388","doi":"10.1126/sciadv.abd1327","title":"Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Parkinsonfonden; National Institutes of Health; IXICO; H. Lundbeck A/S; Knut och Alice Wallenbergs Stiftelse; Servier; Skånes universitetssjukhus; Vetenskapsrådet; Eisai; Lunds Universitet; Svenska Forskningsrådet Formas; NIH Clinical Center; F. Hoffmann-La Roche; Australian Government; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; Janssen Alzheimer Immunotherapy Research And Development; Hjärnfonden; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; Genentech; Marcus och Amalia Wallenbergs minnesfond; Avid Radiopharmaceuticals; Parkinson Research Foundation; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Tau pathology; Disease; Pathology; Alzheimer's disease; Medicine; Neuroscience; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266248,0.0001087504,0.0002061009,0.0001531482,0.0000733759,0.0000094637,0.0001139973,0.00002070155,0.00004039349],"category_scores_gemma":[0.0003455628,0.00008825694,0.00005715296,0.0006895278,0.0006828608,0.0004126982,0.00004695315,0.00008804489,0.00001754924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000436101,"about_ca_system_score_gemma":0.000563027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001373622,"about_ca_topic_score_gemma":0.000005997921,"domain_scores_codex":[0.9984802,0.00005442678,0.0002044502,0.0004119537,0.0005231191,0.0003258334],"domain_scores_gemma":[0.9990245,0.00005416757,0.00008327485,0.0002042427,0.0001213318,0.0005125057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001933914,0.001193676,0.9445035,0.00007596553,0.0001665736,0.0005367314,0.0003356478,0.0002554237,0.009451755,0.00007537977,0.00004097653,0.04143042],"study_design_scores_gemma":[0.006652469,0.004178228,0.8905661,0.000319236,0.0003797145,0.000009753173,0.000641103,0.005177632,0.09088123,0.0004990833,0.0004463848,0.000249132],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897704,0.007870301,0.00008286333,0.001185811,0.00009075874,0.0005431433,0.0001518911,0.00004139547,0.0002635083],"genre_scores_gemma":[0.9991954,0.00005135834,0.0003338347,0.0003156806,0.00002338883,0.00004134755,0.00003162903,0.000006843775,5.385239e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08142947,"threshold_uncertainty_score":0.3599013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04359039739783836,"score_gpt":0.330661865838831,"score_spread":0.2870714684409926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}