{"id":"W3109454598","doi":"10.1161/strokeaha.120.029789","title":"Phase 1b Study to Evaluate Safety, Tolerability, and Maximum Tolerated Dose of PF-05230907 for Intracerebral Hemorrhage","year":2020,"lang":"en","type":"article","venue":"Stroke","topic":"Intracerebral and Subarachnoid Hemorrhage Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Medicine; Tolerability; Intracerebral hemorrhage; Dosing; Population; Dose-ranging study; Clinical trial; Anesthesia; Deep vein; Thrombosis; Adverse effect; Internal medicine; Placebo; Double blind","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002602808,0.0009876757,0.001368731,0.0002750063,0.0002447827,0.0004749073,0.0006935826,0.0008012002,0.002606791],"category_scores_gemma":[0.001367993,0.0003253992,0.0005794283,0.0003270466,0.0006106732,0.0003650269,0.0001694565,0.001627784,0.0005524239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006276752,"about_ca_system_score_gemma":0.00149944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005944227,"about_ca_topic_score_gemma":0.001306975,"domain_scores_codex":[0.9991116,0.0005948012,0.00004296887,0.00009215329,0.00009011941,0.00006822542],"domain_scores_gemma":[0.9988984,0.000248194,0.000401515,0.00008722097,0.00007567511,0.0002888768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7431139,0.05604714,0.01947995,0.0007616259,0.002465952,0.0003720384,0.000171041,0.002560638,0.06773432,0.0002442421,0.002605998,0.1044431],"study_design_scores_gemma":[0.3562289,0.6056414,0.02624669,0.00003525821,0.0004748189,0.0006546535,0.00003076332,0.001676506,0.0068606,0.0001915153,0.001928653,0.00003036105],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929895,0.001669357,0.001276509,0.0002116174,0.00003703283,0.002548268,0.000633865,0.0000716459,0.0005620251],"genre_scores_gemma":[0.9911584,0.000812988,0.003487848,0.0005062117,0.00007878439,0.002234058,0.001042864,0.00002137215,0.0006574558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002606791,"threshold_uncertainty_score":0.0137651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04509492182712192,"score_gpt":0.3556199658301867,"score_spread":0.3105250440030648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}