{"id":"W3109625109","doi":"10.1016/j.ctarc.2020.100249","title":"Association between continuous decrease of plasma VEGF-A levels and the efficacy of chemotherapy in combination with anti-programmed cell death 1 antibody in non-small cell lung cancer patients","year":2020,"lang":"en","type":"article","venue":"Cancer Treatment and Research Communications","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Company; Eli Lilly Japan; Chugai Pharmaceutical; Pfizer Japan; MSD K.K.; Eisai; Ono Pharmaceutical; Bristol-Myers Squibb Canada; Novartis; Otsuka Pharmaceutical; Astellas Pharma; Kyowa Hakko Kirin; Taiho Pharmaceutical; AstraZeneca","keywords":"Lung cancer; Vascular endothelial growth factor; Medicine; Chemotherapy; Internal medicine; Oncology; Antibody; Cancer; VEGF receptors; Gastroenterology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002631759,0.00009852486,0.0002236242,0.00005427426,0.00008570137,0.00001477625,0.0001927434,0.00007781867,0.000003665876],"category_scores_gemma":[0.00003586628,0.00006795253,0.00003649555,0.0002155259,0.0001776239,0.000006151498,0.0000958957,0.00008978349,7.697258e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008812581,"about_ca_system_score_gemma":0.0001783867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00198598,"about_ca_topic_score_gemma":0.0006188177,"domain_scores_codex":[0.9991134,0.000213331,0.000205095,0.0001770749,0.0001250082,0.0001660746],"domain_scores_gemma":[0.9991352,0.0001943512,0.000141925,0.0002587369,0.0002057081,0.00006407271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002531078,0.0004251707,0.9810211,0.00005308036,0.0001103856,1.34261e-7,0.001154422,0.00001504775,0.01223217,0.00001204643,0.0000242232,0.00469909],"study_design_scores_gemma":[0.01479597,0.0006034663,0.9180609,0.0001007162,0.00008615329,5.157419e-8,0.0002673921,0.0006853572,0.06469216,0.000006899219,0.0005928469,0.0001081125],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917003,0.006074391,0.00001711924,0.001183762,0.000006189628,0.0008120018,0.00007323025,0.000001863388,0.0001311548],"genre_scores_gemma":[0.9779575,0.02145362,0.0001458443,0.00002486857,0.00001765697,0.000212906,0.0001225414,0.00001196058,0.00005310562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06296025,"threshold_uncertainty_score":0.3002221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03950006070525217,"score_gpt":0.3540200462152083,"score_spread":0.3145199855099561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}