{"id":"W3109625109","doi":"10.1016/j.ctarc.2020.100249","title":"Association between continuous decrease of plasma VEGF-A levels and the efficacy of chemotherapy in combination with anti-programmed cell death 1 antibody in non-small cell lung cancer patients","year":2020,"lang":"en","type":"article","venue":"Cancer Treatment and Research Communications","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Company; Eli Lilly Japan; Chugai Pharmaceutical; Pfizer Japan; MSD K.K.; Eisai; Ono Pharmaceutical; Bristol-Myers Squibb Canada; Novartis; Otsuka Pharmaceutical; Astellas Pharma; Kyowa Hakko Kirin; Taiho Pharmaceutical; AstraZeneca","keywords":"Lung cancer; Vascular endothelial growth factor; Medicine; Chemotherapy; Internal medicine; Oncology; Antibody; Cancer; VEGF receptors; Gastroenterology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004264314,0.0001710839,0.0003737796,0.0003020545,0.0002425108,0.0003391687,0.0001953379,0.0004491991,0.0008389242],"category_scores_gemma":[0.001599583,0.0001761143,0.0002643535,0.0003896124,0.0001698358,0.0002675259,0.0001716125,0.0005249062,0.0001273805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002344101,"about_ca_system_score_gemma":0.0002120776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00044466,"about_ca_topic_score_gemma":0.0006780522,"domain_scores_codex":[0.9996527,0.00009480238,0.00004869121,0.00008564077,0.00006878463,0.00004934449],"domain_scores_gemma":[0.9981744,0.0005674507,0.0007349053,0.0000622106,0.0001453892,0.0003156261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001783145,0.00009949461,0.9940871,0.00001281472,0.00006669122,0.0001448782,0.00001834696,0.0001346619,0.00139242,0.000009604255,0.00004839814,0.002202457],"study_design_scores_gemma":[0.00005661484,0.001356012,0.9966729,0.000005196184,0.0000565653,0.0006397759,0.0000380868,0.0006134057,0.0003357977,0.0000171346,0.0002037255,0.000004741758],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991828,0.0004636635,0.00005900785,0.00001972444,0.000005247644,0.000005761046,0.00005596744,0.000002767152,0.0002051312],"genre_scores_gemma":[0.9997178,0.00005531284,0.00004609869,0.000009815783,0.000009577369,0.000006789202,0.00007974001,7.434359e-7,0.00007414229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008389242,"threshold_uncertainty_score":0.002806544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03950006070525217,"score_gpt":0.3540200462152083,"score_spread":0.3145199855099561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}