{"id":"W3109646113","doi":"10.1093/ehjci/ehaa946.3380","title":"Favorable therapeutic index of an orally-active small-molecule antagonist of the platelet protease-activated receptor-4, BMS-986141, compared with the P2Y12 antagonist ticagrelor in cynomolgus monkeys","year":2020,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Medicine; Pharmacology; P2Y12; Platelet; Ticagrelor; Antagonist; Platelet activation; Thrombin; In vivo; Ex vivo; Receptor antagonist; Receptor; In vitro; Internal medicine; Aspirin; Chemistry; Biochemistry; Clopidogrel; Platelet aggregation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690238,0.0003381511,0.0005721911,0.0003103545,0.000169087,0.0003736175,0.0001185722,0.0003182947,0.001347045],"category_scores_gemma":[0.0001755155,0.0001132573,0.0001860054,0.0001513333,0.0001976083,0.0002309529,0.0001089114,0.0005585329,0.0003743758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002081576,"about_ca_system_score_gemma":0.0002617922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005440582,"about_ca_topic_score_gemma":0.000705131,"domain_scores_codex":[0.9999101,0.00002121455,0.000004935505,0.00001741691,0.0000157285,0.00003057759],"domain_scores_gemma":[0.9999204,0.00001000727,0.00002010699,0.000008002943,0.00000630734,0.00003512029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01012176,0.001860549,0.001151817,0.00008821077,0.00005089308,0.0002757924,0.00006335818,0.0002277229,0.9637129,0.0001945766,0.0005678253,0.02168454],"study_design_scores_gemma":[0.003509653,0.3144085,0.05094425,0.00004567484,0.0006602486,0.00339225,0.0002064707,0.004440091,0.604707,0.0005637824,0.01706701,0.00005504648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965401,0.001166483,0.0002753806,0.0001236675,0.00003279521,0.00004434298,0.0001675833,0.00003826214,0.00161142],"genre_scores_gemma":[0.9966779,0.001100396,0.0003911864,0.00008922547,0.00005823902,0.00006256768,0.0003410858,0.00001141494,0.001268144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001347045,"threshold_uncertainty_score":0.00450629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03541499104678186,"score_gpt":0.25795512135049,"score_spread":0.2225401303037082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}