{"id":"W3109661160","doi":"10.1126/sciadv.aba4905","title":"Germline genomic patterns are associated with cancer risk, oncogenic pathways, and clinical outcomes","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Chinese Government Scholarship; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Germline; Cancer; Biology; Genetics; Computational biology; Bioinformatics; Cancer research; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003768401,0.0001653104,0.0002646965,0.001016729,0.0001958397,0.0004406533,0.0001688597,0.0002958101,0.001307423],"category_scores_gemma":[0.002245367,0.00009602876,0.0002550091,0.001012842,0.0003424999,0.0002507826,0.000528036,0.0002919523,0.0001220425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001431281,"about_ca_system_score_gemma":0.0001933455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000997104,"about_ca_topic_score_gemma":0.001479066,"domain_scores_codex":[0.9995587,0.00009308544,0.00003697764,0.000172113,0.00006557453,0.00007359964],"domain_scores_gemma":[0.9989417,0.0003424238,0.0004086277,0.0001090718,0.00007855782,0.0001196257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001389518,0.000008411237,0.9895642,0.00001601668,0.0001414652,0.0001224262,0.00004555031,0.000152647,0.004038466,0.00009040509,0.00004963177,0.005631815],"study_design_scores_gemma":[0.000004383675,0.00005812848,0.9969554,0.00000596871,0.0001019256,0.0005576527,0.0001147481,0.0004886038,0.0009361014,0.0004701069,0.0003023861,0.000004628344],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982458,0.0004084751,0.0005937204,0.00003892494,0.000003370593,0.000004037609,0.0003657873,0.00001018683,0.0003297573],"genre_scores_gemma":[0.9994708,0.00008531984,0.0001878817,0.000008973155,0.000003114706,0.000002003935,0.0001926363,0.000002849924,0.00004647899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001307423,"threshold_uncertainty_score":0.004373789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02071596571268627,"score_gpt":0.3076917325309425,"score_spread":0.2869757668182562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}