{"id":"W3109702364","doi":"10.1136/bmjopen-2020-040162","title":"Phase I feasibility study of Magnetic Resonance guided High Intensity Focused Ultrasound-induced hyperthermia, Lyso-Thermosensitive Liposomal Doxorubicin and cyclophosphamide in <i>de novo</i> stage IV breast cancer patients: study protocol of the i-GO study","year":2020,"lang":"en","type":"article","venue":"BMJ Open","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Center for Translational Molecular Medicine; KWF Kankerbestrijding; Universitair Medisch Centrum Utrecht","keywords":"Medicine; Doxorubicin; Breast cancer; Hyperthermia; Cyclophosphamide; Tolerability; Chemotherapy; Clinical endpoint; Cancer; Internal medicine; Oncology; Adverse effect; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005368806,0.0003470664,0.0007756529,0.00004600956,0.0001145744,0.0000559169,0.000701743,0.00007306227,0.00004694886],"category_scores_gemma":[0.0001466437,0.0002706917,0.00005420808,0.0006706722,0.00008343852,0.0001812,0.0003301528,0.000291729,0.000002101355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001429773,"about_ca_system_score_gemma":0.0001294971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005107061,"about_ca_topic_score_gemma":0.004843981,"domain_scores_codex":[0.9973999,0.0003843346,0.0009008716,0.00058069,0.0004193038,0.0003148826],"domain_scores_gemma":[0.9983835,0.0001705967,0.0002348413,0.0008120351,0.000279248,0.0001198134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00192656,0.0127945,0.912846,0.0001081836,0.0001013764,0.00001160086,0.01973544,0.0002979132,0.04864313,0.000002281777,0.00002640201,0.003506658],"study_design_scores_gemma":[0.02062062,0.003082115,0.9634715,0.00008910349,0.00009288763,0.000005276178,0.007131473,0.0002769114,0.004899854,0.000007158782,0.0000168128,0.0003062667],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7840014,0.000006429139,0.000001369498,0.00006543566,0.00003272128,0.215602,0.0001560002,0.00004155099,0.00009303062],"genre_scores_gemma":[0.9324266,0.000001331588,0.00003712278,0.0001010423,0.00003068906,0.06732357,0.000002534477,0.00005506719,0.00002206159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1484252,"threshold_uncertainty_score":0.9999745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04390269291348041,"score_gpt":0.3372606346785856,"score_spread":0.2933579417651052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}