{"id":"W3109702364","doi":"10.1136/bmjopen-2020-040162","title":"Phase I feasibility study of Magnetic Resonance guided High Intensity Focused Ultrasound-induced hyperthermia, Lyso-Thermosensitive Liposomal Doxorubicin and cyclophosphamide in <i>de novo</i> stage IV breast cancer patients: study protocol of the i-GO study","year":2020,"lang":"en","type":"article","venue":"BMJ Open","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Center for Translational Molecular Medicine; KWF Kankerbestrijding; Universitair Medisch Centrum Utrecht","keywords":"Medicine; Doxorubicin; Breast cancer; Hyperthermia; Cyclophosphamide; Tolerability; Chemotherapy; Clinical endpoint; Cancer; Internal medicine; Oncology; Adverse effect; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002513398,0.002462609,0.003123047,0.0005697061,0.0006597922,0.00109803,0.001642419,0.001952776,0.004839362],"category_scores_gemma":[0.0009765062,0.0009971951,0.001442281,0.0005646887,0.00162926,0.0007158455,0.0007057266,0.002399485,0.001858676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001181934,"about_ca_system_score_gemma":0.004023149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001372844,"about_ca_topic_score_gemma":0.001851713,"domain_scores_codex":[0.9988042,0.0005667672,0.00005374508,0.0002188142,0.00009850328,0.0002579919],"domain_scores_gemma":[0.9991294,0.00008559837,0.0001454311,0.0001399056,0.00007471109,0.0004250306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7000554,0.1384407,0.004198063,0.001361068,0.0006304536,0.0003781721,0.0004798857,0.002502598,0.119215,0.0004588551,0.002549667,0.02973018],"study_design_scores_gemma":[0.291161,0.688042,0.004607343,0.00004443976,0.0003997016,0.000230843,0.00008677556,0.0003757188,0.009243282,0.0001752647,0.005597604,0.00003602488],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9343185,0.001382139,0.002832263,0.0004371216,0.0001998144,0.05640414,0.001864614,0.0001068519,0.002454578],"genre_scores_gemma":[0.8669431,0.002189627,0.008025826,0.001490099,0.0003781025,0.1105392,0.00468207,0.00009195106,0.005659967],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.004839362,"threshold_uncertainty_score":0.01618928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04390269291348041,"score_gpt":0.3372606346785856,"score_spread":0.2933579417651052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}