{"id":"W3109706750","doi":"10.1002/ana.26032","title":"Heritability Enrichment Implicates Microglia in Parkinson's Disease Pathogenesis","year":2021,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"UCLH Biomedical Research Centre; Helse Sør-Øst RHF; Medical Research Council; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Institutes of Health; University College London Hospitals NHS Foundation Trust; UK Dementia Research Institute; Nasjonalforeningen for Folkehelsen; National Institute for Health and Care Research; Medical Research Council Canada; Wellcome Trust; Alzheimer's Society; University College London","keywords":"Microglia; Parkinson's disease; Biology; Disease; Heritability; Pathogenesis; Genome-wide association study; Neuroscience; Linkage disequilibrium; Genetic association; Genetics; Bioinformatics; Immunology; Medicine; Single-nucleotide polymorphism; Gene; Pathology; Genotype; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00307588,0.0006466928,0.000725936,0.001203114,0.000432382,0.0009419632,0.000501169,0.0004879206,0.003127137],"category_scores_gemma":[0.005795439,0.0002865376,0.001694252,0.001438128,0.000621484,0.0003716539,0.0009202522,0.0004532192,0.000180784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002534641,"about_ca_system_score_gemma":0.0004625635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003008402,"about_ca_topic_score_gemma":0.004579954,"domain_scores_codex":[0.9974511,0.001031879,0.0002111052,0.0008083908,0.0003216966,0.0001759119],"domain_scores_gemma":[0.9948547,0.002543439,0.001524672,0.0007258004,0.0002060649,0.0001452846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009844402,0.00003012795,0.9484327,0.0004049794,0.010008,0.0007246453,0.0002425335,0.00216216,0.01309606,0.0008107706,0.0005911406,0.02251246],"study_design_scores_gemma":[0.00004542651,0.0001878789,0.9854187,0.00008743005,0.004735588,0.000912481,0.0001374204,0.00321216,0.001762417,0.002424262,0.001057498,0.00001877142],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715119,0.01205462,0.01193923,0.0008326729,0.00005825322,0.0000238083,0.001906543,0.0001667623,0.00150612],"genre_scores_gemma":[0.9977254,0.0006053042,0.001125877,0.00004224288,0.00003183722,0.000005989418,0.0002844082,0.00001637869,0.0001626394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003127137,"threshold_uncertainty_score":0.016267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06866660239285806,"score_gpt":0.310085781251385,"score_spread":0.241419178858527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}