{"id":"W3109777100","doi":"10.3310/eme07090","title":"Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCT","year":2020,"lang":"en","type":"article","venue":"Efficacy and Mechanism Evaluation","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre","funders":"St. George's, University of London; National Institutes of Health; James Cook University; University of Nottingham; University of Southampton; Medical Research Council; National Institute for Social Care and Health Research; Public Health Agency; Efficacy and Mechanism Evaluation Programme; National Institute for Health and Care Research","keywords":"Ursodeoxycholic acid; Medicine; Cholestasis of pregnancy; Pregnancy; Placebo; Randomized controlled trial; Gestation; Obstetrics; Cholestasis; Adverse effect; Internal medicine; Fetus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004376862,0.0009003193,0.002690658,0.0005915426,0.0003939179,0.001114635,0.0006228301,0.001867571,0.01034741],"category_scores_gemma":[0.01087554,0.0004783761,0.004002464,0.0005247936,0.0007102364,0.0009333031,0.001064397,0.001767751,0.0005915738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007591492,"about_ca_system_score_gemma":0.001689705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002613258,"about_ca_topic_score_gemma":0.003550872,"domain_scores_codex":[0.996808,0.002187061,0.000385716,0.0002616219,0.0002108456,0.0001467647],"domain_scores_gemma":[0.9976756,0.001175999,0.0005314649,0.0002114747,0.0001659314,0.0002395742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8104594,0.002088477,0.00326219,0.04552449,0.02014498,0.0003268122,0.0004401745,0.0006585023,0.002504764,0.001621113,0.003907369,0.1090619],"study_design_scores_gemma":[0.9209133,0.03368025,0.008753974,0.006407239,0.01647907,0.0002000757,0.0002677299,0.0002157331,0.0004777468,0.001084935,0.01147914,0.00004081869],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6990181,0.2376971,0.00278685,0.009354358,0.00476883,0.02190666,0.007170108,0.0002109823,0.01708715],"genre_scores_gemma":[0.8941409,0.06876929,0.004850878,0.004346065,0.001429096,0.01596504,0.001497326,0.0000432891,0.008958256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01034741,"threshold_uncertainty_score":0.03461558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05651000613138751,"score_gpt":0.3303801698381169,"score_spread":0.2738701637067293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}