{"id":"W3109826407","doi":"10.3390/ijms22010268","title":"The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity","year":2020,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council Canada; Academy of Finland","keywords":"Cell biology; Transcription factor; Hypoxia-Inducible Factor 1; Hypoxia (environmental); Hypoxia-inducible factors; Hydroxylation; Cellular adaptation; Hedgehog signaling pathway; Chemistry; Homeostasis; Limiting; Biology; Signal transduction; Biochemistry; Gene; Oxygen; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000640892,0.0001622666,0.0003786103,0.0001553075,0.00008358199,0.0000833474,0.0006736168,0.000116894,0.000007146397],"category_scores_gemma":[0.0004449282,0.0001183359,0.0002372985,0.0002139508,0.0002546914,0.00002961317,0.0001080458,0.0001941944,4.892781e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002862547,"about_ca_system_score_gemma":0.0009611589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002119657,"about_ca_topic_score_gemma":0.00003693111,"domain_scores_codex":[0.998179,0.0001991504,0.0006140475,0.0002689895,0.000606377,0.0001324962],"domain_scores_gemma":[0.9984067,0.0001094295,0.0007361622,0.0001352448,0.0005428902,0.0000695465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000038764,0.00006209511,0.00006021611,0.0001250446,0.0001803804,0.000001788337,0.0001722602,0.0001374429,0.08954389,0.001392383,0.000009356822,0.9082764],"study_design_scores_gemma":[0.0005389373,0.0002461117,0.000736314,0.001015212,0.0001565023,0.0002021709,0.0002989508,0.0004324898,0.05050086,0.001469447,0.9440292,0.000373782],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02512501,0.9725751,0.0009102256,0.0004171886,0.0005385266,0.000195823,0.00009116209,0.000001683731,0.0001453022],"genre_scores_gemma":[0.2713393,0.7278889,0.00034465,0.00002291902,0.0003676748,0.000007276977,0.0000120299,0.00001048447,0.000006713581],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9440199,"threshold_uncertainty_score":0.4825598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04423786956527276,"score_gpt":0.3310232970084058,"score_spread":0.2867854274431331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}