{"id":"W3109853980","doi":"10.1016/s0140-6736(20)32531-9","title":"Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial","year":2020,"lang":"en","type":"article","venue":"The Lancet","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1800,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Carboplatin; Gemcitabine; Internal medicine; Pembrolizumab; Triple-negative breast cancer; Breast cancer; Oncology; Chemotherapy; Docetaxel; Metastatic breast cancer; Placebo; Taxane; Cancer; Pathology; Cisplatin; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001801561,0.002071189,0.003490606,0.0005519,0.0004993777,0.001171895,0.001110336,0.00225999,0.01014401],"category_scores_gemma":[0.001634623,0.0008056305,0.002077576,0.0004650534,0.001339599,0.001270415,0.0004831637,0.003170807,0.00169523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007851884,"about_ca_system_score_gemma":0.001043835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001361051,"about_ca_topic_score_gemma":0.002576913,"domain_scores_codex":[0.999463,0.0002400146,0.00003210411,0.0001297819,0.00003654863,0.00009861179],"domain_scores_gemma":[0.9993955,0.000193726,0.0001313913,0.00004515854,0.00003348701,0.000200748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9859915,0.003186912,0.0001014813,0.0005923121,0.0004168491,0.00001771515,0.0000302399,0.0001515259,0.001483654,0.00008967397,0.0004471189,0.007490886],"study_design_scores_gemma":[0.9634804,0.03511599,0.0004154814,0.00003166476,0.0002191072,0.00001269688,0.00001180516,0.0001550773,0.0001515419,0.00009423377,0.0003032076,0.000008921486],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712752,0.01070049,0.00128197,0.001321441,0.001779539,0.007700333,0.001691805,0.000289314,0.003959995],"genre_scores_gemma":[0.9735314,0.005897978,0.002213702,0.001990512,0.0007476402,0.007352525,0.001154157,0.0000417314,0.007070308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01014401,"threshold_uncertainty_score":0.03393513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1378372333894381,"score_gpt":0.4138224453152746,"score_spread":0.2759852119258366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}