{"id":"W3109862518","doi":"10.1016/j.celrep.2020.108466","title":"Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020; Medical Research Council; Centre National de la Recherche Scientifique; ULB Center for Diabetes Research; Fonds De La Recherche Scientifique - FNRS; Singapore Eye Research Institute; European Commission; Institut national de la recherche scientifique; Wellcome Trust; Agence Nationale de la Recherche; Juvenile Diabetes Research Foundation United States of America; Horizon 2020 Framework Programme; Leona M. and Harry B. Helmsley Charitable Trust; Janssen Research and Development; Société Francophone du Diabète; Innoviris; Equipex; European Federation of Pharmaceutical Industries and Associations; Innovative Medicines Initiative; Wellcome","keywords":"Islet; Transcriptome; Biology; Type 2 diabetes; Gene expression; Gene; Cell type; Cell; Cell biology; Insulin; Diabetes mellitus; Genetics; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741773,0.000153503,0.0002020506,0.0003291784,0.0001666772,0.0004037266,0.00007398877,0.0001421178,0.001140348],"category_scores_gemma":[0.0001837015,0.00008324727,0.0002733967,0.0004794174,0.0002363861,0.0001326447,0.0003024309,0.00023541,0.0001600065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000107974,"about_ca_system_score_gemma":0.0001054112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003203505,"about_ca_topic_score_gemma":0.0003991528,"domain_scores_codex":[0.9998868,0.00001457142,0.00001009875,0.00003845763,0.00002772698,0.00002225341],"domain_scores_gemma":[0.9998437,0.00002218037,0.00006316196,0.00002586198,0.00001855669,0.00002641176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007100719,0.00004437953,0.04140072,0.00006908645,0.00004725366,0.0001907143,0.0001409303,0.0001466825,0.951306,0.00004168077,0.0000616679,0.005840736],"study_design_scores_gemma":[0.00001568451,0.0005103894,0.8533142,0.00001295922,0.00009665157,0.001075233,0.0003979565,0.0004555396,0.1423078,0.0001725834,0.001625735,0.00001533215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976823,0.0006007929,0.0008993332,0.00002289028,0.000005177592,0.000008800052,0.0004777024,0.00001432204,0.0002886371],"genre_scores_gemma":[0.9964215,0.0006895465,0.001115475,0.00004894985,0.000006713901,0.0000276298,0.001074886,0.00001450167,0.0006007745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140348,"threshold_uncertainty_score":0.003814876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02261415838442164,"score_gpt":0.2200188222236141,"score_spread":0.1974046638391925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}