{"id":"W3109921601","doi":"10.1093/ehjci/ehaa946.3689","title":"Pathological phosphorylation of the ryanodine receptor at s2808 increases the number of individual clusters activated per calcium spark and the calcium released per cluster","year":2020,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"","keywords":"Ryanodine receptor; Ryanodine receptor 2; Calcium; Medicine; Biophysics; Phosphorylation; Internal medicine; Endocrinology; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001868486,0.0002196886,0.0003419018,0.0002812259,0.0001247975,0.0003073871,0.000183358,0.0002547901,0.002827753],"category_scores_gemma":[0.0002259289,0.0001820037,0.0002706414,0.00009938257,0.0002850941,0.0002152642,0.0002930159,0.0003446537,0.0003696784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001746422,"about_ca_system_score_gemma":0.0001077596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001941759,"about_ca_topic_score_gemma":0.000173795,"domain_scores_codex":[0.9998215,0.00001728755,0.00002135074,0.00005614504,0.00004257446,0.00004124043],"domain_scores_gemma":[0.9997032,0.00004357511,0.00009291458,0.00002563736,0.00002922204,0.0001053771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002633262,0.00003054269,0.0009708386,0.00001971873,0.000009019633,0.0000524978,0.00001187003,0.00004726156,0.997789,0.00003134377,0.00003068086,0.0007438104],"study_design_scores_gemma":[0.00009871071,0.001254806,0.1246025,0.00001491438,0.00006240896,0.001587081,0.0001602254,0.004092041,0.8665966,0.0002054191,0.001308076,0.00001719236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981201,0.0001765977,0.001173663,0.00002810616,0.00001020013,0.000005688686,0.00006099337,0.00004216615,0.0003822831],"genre_scores_gemma":[0.9980403,0.0001013623,0.00100034,0.00001968167,0.000006690113,0.00001747009,0.0001037394,0.00001822694,0.0006922893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002827753,"threshold_uncertainty_score":0.009459794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0325489119732594,"score_gpt":0.2766559776680332,"score_spread":0.2441070656947738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}