{"id":"W3109953138","doi":"10.1002/onco.13626","title":"Implementing <i>DPYD*2A</i> Genotyping in Clinical Practice: The Quebec, Canada, Experience","year":2020,"lang":"en","type":"article","venue":"The Oncologist","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré de Santé et de Services Sociaux des Laurentides; Centre Hospitalier Universitaire de Sherbrooke; Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec; Développement Economique Longueuil; Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"DPYD; Medicine; Mucositis; Internal medicine; Chemotherapy; Capecitabine; Genotyping; Dihydropyrimidine dehydrogenase; Oncology; Fluorouracil; Gastroenterology; Rash; Cancer; Pharmacogenetics; Genotype; Colorectal cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002852732,0.0004966423,0.0002499207,0.0004986048,0.002285013,0.001678063,0.00135733,0.0007124525,0.001954998],"category_scores_gemma":[0.006294449,0.0003000961,0.0002190956,0.001735097,0.001189209,0.0005354114,0.0009281509,0.0009203067,0.000302217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.04117776,"about_ca_system_score_gemma":0.07937709,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9857799,"about_ca_topic_score_gemma":0.989842,"domain_scores_codex":[0.9967908,0.0006696034,0.0001545172,0.0004570875,0.001208653,0.0007192885],"domain_scores_gemma":[0.98485,0.0009259298,0.001136101,0.0003107071,0.007614774,0.005162418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006448442,0.0008878552,0.761946,0.0003945739,0.0001030964,0.001784152,0.006188374,0.001797548,0.005085628,0.000651001,0.01972307,0.2007938],"study_design_scores_gemma":[0.0002375952,0.001629286,0.9552472,0.0003291493,0.00007387577,0.001161662,0.00468833,0.002177915,0.001065342,0.0001075348,0.03320045,0.00008170692],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9521251,0.008693595,0.002245022,0.01209536,0.000232452,0.0007674907,0.001728868,0.0001746374,0.02193733],"genre_scores_gemma":[0.9845157,0.003504437,0.003428299,0.003230975,0.00007894193,0.0000964921,0.0009060777,0.00005710962,0.004181965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04117776,"threshold_uncertainty_score":0.298767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07498892060660377,"score_gpt":0.4088861677568453,"score_spread":0.3338972471502415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}