{"id":"W3109953138","doi":"10.1002/onco.13626","title":"Implementing <i>DPYD*2A</i> Genotyping in Clinical Practice: The Quebec, Canada, Experience","year":2020,"lang":"en","type":"article","venue":"The Oncologist","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré de Santé et de Services Sociaux des Laurentides; Centre Hospitalier Universitaire de Sherbrooke; Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec; Développement Economique Longueuil; Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"DPYD; Medicine; Mucositis; Internal medicine; Chemotherapy; Capecitabine; Genotyping; Dihydropyrimidine dehydrogenase; Oncology; Fluorouracil; Gastroenterology; Rash; Cancer; Pharmacogenetics; Genotype; Colorectal cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005936206,0.0001058473,0.0002494325,0.000005939515,0.0003066615,0.00002206415,0.0001684942,0.00002994548,0.00007073748],"category_scores_gemma":[0.001265472,0.00005187604,0.00005500872,0.0001764154,0.0002050965,0.00004367367,0.0002049802,0.0002903242,0.000006829957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003604555,"about_ca_system_score_gemma":0.0007196397,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.6422712,"about_ca_topic_score_gemma":0.9564162,"domain_scores_codex":[0.9987457,0.0001440349,0.0003692313,0.0002102937,0.0002164377,0.0003142341],"domain_scores_gemma":[0.9987601,0.0007863513,0.0001418446,0.0001893136,0.00005483688,0.00006754382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003713005,0.0006400606,0.4355838,0.00008827295,0.0007140161,0.001534556,0.04286991,0.00004860959,0.0003884559,0.001659425,0.1877163,0.3250436],"study_design_scores_gemma":[0.00096898,0.0002919443,0.2495293,0.00001646159,0.00009850791,0.00001540429,0.02099984,0.0001081817,0.00006051317,0.00001000675,0.7278167,0.00008411072],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7006398,0.002841116,0.00002365762,0.2635948,0.0003463933,0.0007622296,0.000005978367,0.00003633324,0.03174966],"genre_scores_gemma":[0.9748731,0.0002787803,0.0001272027,0.02386329,0.0003442055,0.00008039075,0.000002417858,0.000007512193,0.000423142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5401004,"threshold_uncertainty_score":0.3601109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07498892060660377,"score_gpt":0.4088861677568453,"score_spread":0.3338972471502415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}