{"id":"W3109958337","doi":"10.1016/j.drudis.2020.11.024","title":"Market access of gene therapies across Europe, USA, and Canada: challenges, trends, and solutions","year":2020,"lang":"en","type":"review","venue":"Drug Discovery Today","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds Wetenschappelijk Onderzoek; Canadian Armed Forces; Vlaamse regering; McMaster University","keywords":"Market access; Drug discovery; Computational biology; Business; Biology; Bioinformatics; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002617879,0.0004387562,0.00082423,0.002810375,0.0006158662,0.002847623,0.000914716,0.001340066,0.005419081],"category_scores_gemma":[0.003279702,0.0002106672,0.0008786718,0.004083395,0.0008104607,0.001940592,0.0009089378,0.002118603,0.0007516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006602892,"about_ca_system_score_gemma":0.02370006,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.09107076,"about_ca_topic_score_gemma":0.1729032,"domain_scores_codex":[0.9989154,0.0001364676,0.00009801682,0.00009812101,0.0005481411,0.0002038096],"domain_scores_gemma":[0.9972198,0.001016489,0.0003213053,0.00003180589,0.001169722,0.0002407818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007326486,0.00006270836,0.001183394,0.01639385,0.0001292963,0.0002445015,0.0002628123,0.000624092,0.001177907,0.01871613,0.04725872,0.9138733],"study_design_scores_gemma":[0.00001713728,0.00007569989,0.002829237,0.009627711,0.0001753088,0.0004740053,0.0004663309,0.0002365476,0.0005129138,0.003259272,0.982294,0.00003190179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000695726,0.9879882,0.0002309059,0.005413837,0.0002339912,0.0000167922,0.0001138897,0.00001454616,0.005292063],"genre_scores_gemma":[0.004138393,0.992935,0.0004456461,0.001177319,0.00009396929,0.00001280749,0.0001138605,0.000004343857,0.001078719],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9089292,"threshold_uncertainty_score":0.1810814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08096664045937163,"score_gpt":0.3571380909215697,"score_spread":0.276171450462198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}