{"id":"W3109969518","doi":"10.1016/j.immuni.2020.11.009","title":"SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation","year":2020,"lang":"en","type":"article","venue":"Immunity","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":400,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Germinal center; Biology; Virology; Neutralizing antibody; Adjuvant; Antibody; Immunization; Memory B cell; Immunology; Immune system; Antigen; Messenger RNA; Recombinant DNA; Coronavirus; B cell; Coronavirus disease 2019 (COVID-19); Disease; Medicine; Gene; Infectious disease (medical specialty); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004320016,0.001137846,0.0004511123,0.0004614387,0.0002629228,0.0004972972,0.0002305381,0.0005943621,0.002827596],"category_scores_gemma":[0.0003821205,0.0002404495,0.0003297586,0.0001355845,0.000385104,0.0003852103,0.0003806605,0.001956082,0.0008383668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000532172,"about_ca_system_score_gemma":0.0004315817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004722076,"about_ca_topic_score_gemma":0.0006341315,"domain_scores_codex":[0.9994841,0.00009713594,0.00002772123,0.00009061208,0.00008650307,0.0002138655],"domain_scores_gemma":[0.9997171,0.00008309836,0.00006321777,0.00003380733,0.00004225727,0.0000605387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004468766,0.000259846,0.0001939433,0.00005631786,0.00001032499,0.00003793354,0.00003400234,0.0002268392,0.9949605,0.0003198469,0.0001712745,0.003282181],"study_design_scores_gemma":[0.0002372904,0.003813699,0.003788387,0.0000189582,0.00004634245,0.000266024,0.0001014712,0.00237548,0.9850618,0.0002335639,0.004047534,0.000009369162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901556,0.0008700808,0.004167102,0.0001705654,0.0002281354,0.0001761791,0.0002916422,0.0002008522,0.003739686],"genre_scores_gemma":[0.9943898,0.0003875445,0.001911487,0.0001284629,0.00008449623,0.00005883097,0.0004046504,0.000039062,0.002595523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002827596,"threshold_uncertainty_score":0.009459198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1299481252726223,"score_gpt":0.3748548873120743,"score_spread":0.2449067620394519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}