{"id":"W3109969518","doi":"10.1016/j.immuni.2020.11.009","title":"SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation","year":2020,"lang":"en","type":"article","venue":"Immunity","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":400,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Germinal center; Biology; Virology; Neutralizing antibody; Adjuvant; Antibody; Immunization; Memory B cell; Immunology; Immune system; Antigen; Messenger RNA; Recombinant DNA; Coronavirus; B cell; Coronavirus disease 2019 (COVID-19); Disease; Medicine; Gene; Infectious disease (medical specialty); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004543709,0.000281391,0.0004208734,0.0001755907,0.0003009859,0.0001338067,0.0002496867,0.0001471974,0.0000168289],"category_scores_gemma":[0.0002343426,0.0002266104,0.0001396548,0.0005415219,0.00009017061,0.0002405745,0.0001417045,0.0006118059,0.00008594376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001322954,"about_ca_system_score_gemma":0.0002007072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002071349,"about_ca_topic_score_gemma":0.00008361685,"domain_scores_codex":[0.9977799,0.0004137249,0.000382429,0.0003895421,0.0005277786,0.0005066104],"domain_scores_gemma":[0.9988383,0.000124528,0.0001291833,0.0004835878,0.0003621965,0.00006222151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001736626,0.000299596,0.1221905,0.00003563189,0.0001246027,0.0002833045,0.0008192692,3.993434e-7,0.8715346,0.000009071103,0.001450806,0.001515649],"study_design_scores_gemma":[0.002829542,0.0007881101,0.1927965,0.0001378713,0.00003609643,0.00008512568,0.0002021546,0.0004564963,0.7618002,0.000005823359,0.0405994,0.0002627096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952863,0.0006122011,0.0002536993,0.002322171,0.0001332097,0.0004914567,0.0000252532,0.0001493267,0.0007264238],"genre_scores_gemma":[0.9704293,0.00005694305,0.0001278269,0.02887452,0.0003316613,0.0000146711,0.00009116204,0.00005162824,0.00002228508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1097344,"threshold_uncertainty_score":0.9240906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1299481252726223,"score_gpt":0.3748548873120743,"score_spread":0.2449067620394519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}