{"id":"W3110006368","doi":"10.1038/s41467-020-19861-z","title":"Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; LabEx BRAIN; Fédération pour la Recherche sur le Cerveau; Centre National de la Recherche Scientifique; Ministerio de Economía y Competitividad; Banco Bilbao Vizcaya Argentaria; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Eusko Jaurlaritza; CHIST-ERA; Agence Nationale de la Recherche; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; National Alliance for Research on Schizophrenia and Depression; Hospital for Sick Children; Canadian Institutes of Health Research; Université de Paris; Fundación BBVA","keywords":"Polyunsaturated fatty acid; Microglia; Synaptic pruning; Offspring; Hippocampal formation; Hippocampus; Biology; Neuroscience; Central nervous system; Phagocytosis; Inflammation; Cell biology; Immunology; Biochemistry; Pregnancy; Fatty acid; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002478496,0.0005725226,0.0003652248,0.001104442,0.0003290062,0.0004163107,0.0004030879,0.0006109102,0.00148286],"category_scores_gemma":[0.0001165784,0.0003635405,0.0004352726,0.0002589007,0.0005731794,0.0003817749,0.0004330864,0.001159554,0.0005419178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006038463,"about_ca_system_score_gemma":0.0004271018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001537938,"about_ca_topic_score_gemma":0.004126619,"domain_scores_codex":[0.9996569,0.00004017036,0.00003990309,0.00008527,0.0000814026,0.00009633566],"domain_scores_gemma":[0.9997759,0.00001917123,0.00007656837,0.0000188931,0.00002326512,0.00008620973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000267007,0.00006700886,0.0003082754,0.00003439381,0.000006373388,0.00006156525,0.00003236936,0.00003158116,0.9981589,0.0001087031,0.00003925814,0.0008845026],"study_design_scores_gemma":[0.00004229556,0.000461478,0.009237518,0.00002647811,0.0000409696,0.0002395409,0.0001368413,0.0005162353,0.9874358,0.0002100467,0.001641892,0.00001090602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909126,0.002537655,0.003145741,0.0003128587,0.00005517489,0.00003889279,0.001122002,0.0001567482,0.001718342],"genre_scores_gemma":[0.9805669,0.003254995,0.006866444,0.0002263607,0.00001813112,0.000169735,0.0008995852,0.0001085444,0.007889346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001537938,"threshold_uncertainty_score":0.004960716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05441135706784777,"score_gpt":0.3174160207819677,"score_spread":0.2630046637141199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}